Validation of an axially distributed model for quantification of myocardial blood flow using ¹³N-ammonia PET.
Validation of an axially distributed model for quantification of myocardial blood flow using ¹³N-ammonia PET.
复制标题
使用Ammonia PET对轴向分布的模型进行轴向分布模型的验证。
DOI：
10.1007/s12350-012-9632-8
复制
发表时间：
2013-02
影响因子：
2.4
通讯作者：
Caldwell, James H.
中科院分区：
文献类型：
--
作者：
Alessio, Adam M.;Bassingthwaighte, James B.;Glenny, Robb;Caldwell, James H.
心脏PET心肌血流量（MBF）的估计通常采用传统的房室模型。在这项研究中，我们开发和评估了一个生理和解剖现实的轴向分布模型。与房室模型不同，这种轴向分布方法对沿毛细血管沿着摄取和保留的时间和空间梯度进行建模。我们在5只狗的19项（9项休息，10项应激）研究中验证了PET衍生的流量估计。放射性示踪剂，13 N-氨，静脉注射，而微球管理到左心房。在5项压力研究中，外部封堵器迫使局部充血流量减少。将轴向分布模型的流量估计值与传统房室模型的估计值进行比较。微球与17个节段中每个节段的轴向分布血流估计值之间的平均差异为0.03 mL/g/min（95% CI [-0.05，0.11]）。对于轴向分布模型，血流量估计值与每个区域微球值高度相关（y = 0.98x + 0.06 mL/g/min; r = 0.74; P <.001），对于双室三房室模型（y = 0.69x +0.54; r = 0.74; P<0.001）。轴向分布模型的估计误差方差高于房室模型（高1.7 +/-0.2倍，平均值+/-1 SD）。建议的轴向分布模型提供了准确的区域估计MBF。与评价的房室模型相比，轴向分布模型估计血流量的准确性更高，但精度较低。
Estimation of myocardial blood flow (MBF) with cardiac PET is often performed with conventional compartmental models. In this study, we developed and evaluated a physiologically and anatomically realistic axially distributed model. Unlike compartmental models, this axially distributed approach models both the temporal and the spatial gradients in uptake and retention along the capillary. We validated PET-derived flow estimates with microsphere studies in 19 (9 rest, 10 stress) studies in five dogs. The radiotracer, 13N-ammonia, was injected intravenously while microspheres were administered into the left atrium. A regional reduction in hyperemic flow was forced by an external occluder in five of the stress studies. The flow estimates from the axially distributed model were compared with estimates from conventional compartmental models. The mean difference between microspheres and the axially distributed blood flow estimates in each of the 17 segments was 0.03 mL/g/minute (95% CI [−0.05, 0.11]). The blood flow estimates were highly correlated with each regional microsphere value for the axially distributed model (y = 0.98x + 0.06 mL/g/minute; r = 0.74; P <.001), for the two-compartment (y = 0.64x + 0.34; r = 0.74; P<.001), and for three-compartment model (y = 0.69x + 0.54; r = 0.74; P<.001). The variance of the error of the estimates is higher with the axially distributed model than the compartmental models (1.7 +/− 0.2 time higher, mean +/− 1 SD). The proposed axially distributed model provided accurate regional estimates of MBF. The axially distributed model estimated blood flow with more accuracy, but less precision, than the evaluated compartmental models.
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影响因子：
37.8
作者：
SCHELBERT, HR;PHELPS, ME;KUHL, DE
通讯作者：
KUHL, DE
影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
20.1
作者：
BASSINGTHWAIGHTE, JB;KING, RB;ROGER, SA
通讯作者：
ROGER, SA
影响因子：
6.3
作者：
LARSON, KB;MARKHAM, J;RAICHLE, ME
通讯作者：
RAICHLE, ME
影响因子：
10.6
作者：
Muzic, RF;Saidel, GM
通讯作者：
Saidel, GM