Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders.
Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders.
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DOI：
10.1038/s41583-022-00641-1
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发表时间：
2023-01
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--
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越来越多的人认识到，非神经元细胞参与了各种神经退行性疾病的发生、发展和病理。本文综述了星形胶质细胞在阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩侧索硬化症等疾病中的作用。考虑到星形胶质细胞在健康大脑中支持神经元功能的重要作用，以及已经证明星形胶质细胞的生理特性如何在神经退行性疾病中改变的研究，并可能解释它们对神经退行性疾病的贡献。此外，本文还讨论了在具有特定基因突变的神经退行性疾病中，这些突变是否直接影响星形胶质细胞的功能，并可能提示星形胶质细胞在疾病起始中的驱动作用。星形胶质细胞转录组学和蛋白质组学特征在神经退行性疾病的进展过程中是如何改变的，并可能与功能改变有关。鉴于星形胶质细胞在神经退行性疾病中的核心作用，本文讨论了针对这些细胞的未来治疗途径的潜在策略。
There is increasing appreciation that non-neuronal cells contribute to the initiation, progression and pathology of diverse neurodegenerative disorders. This review focuses on the role of astrocytes in disorders including Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease and Amyotrophic Lateral Sclerosis. The important roles astrocytes have in supporting neuronal function in the healthy brain are considered, along with studies that have demonstrated how the physiological properties of astrocytes are altered in neurodegenerative disorders and may explain their contribution to neurodegeneration. Further, the question of whether in neurodegenerative disorders with specific genetic mutations these mutations directly impact on astrocyte function, and may suggest a driving role for astrocytes in disease initiation, is discussed. A summary of how astrocyte transcriptomic and proteomic signatures are altered during the progression of neurodegenerative disorders and may relate to functional changes is provided. Given the central role of astrocytes in neurodegenerative disorders, potential strategies to target these cells for future therapeutic avenues is discussed.
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影响因子：
9.3
作者：
Al-Ramahi I;Lu B;Di Paola S;Pang K;de Haro M;Peluso I;Gallego-Flores T;Malik NT;Erikson K;Bleiberg BA;Avalos M;Fan G;Rivers LE;Laitman AM;Diaz-García JR;Hild M;Palacino J;Liu Z;Medina DL;Botas J
通讯作者：
Botas J
影响因子：
16.2
作者：
Bai, Bing;Wang, Xusheng;Peng, Junmin
通讯作者：
Peng, Junmin
影响因子：
56.9
作者：
Bindocci, Erika;Savtchouk, Iaroslav;Volterra, Andrea
通讯作者：
Volterra, Andrea
来自小鼠大脑多个区域的老化星形胶质细胞转录组。
影响因子：
8.8
作者：
Boisvert MM;Erikson GA;Shokhirev MN;Allen NJ
通讯作者：
Allen NJ
影响因子：
14.5
作者：
Birolini, Giulia;Verlengia, Gianluca;Valenza, Marta
通讯作者：
Valenza, Marta