Functional connections between cell cycle and proteostasis in the regulation of Candida albicans morphogenesis.
Functional connections between cell cycle and proteostasis in the regulation of Candida albicans morphogenesis.
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DOI：
10.1016/j.celrep.2021.108781
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发表时间：
2021-02-23
期刊：
影响因子：
8.8
通讯作者：
Cowen LE
中科院分区：
文献类型：
--
作者：
Hossain S;Lash E;Veri AO;Cowen LE
形态可塑性是许多真菌病原体的关键毒力特征。对于机会性真菌病原体白色念珠菌来说，酵母、假菌丝和菌丝形态之间的转变对于毒力至关重要，因为形态型在感染过程中发挥着不同的作用。白色念珠菌形态发生是响应许多宿主相关条件而诱导的，并受到复杂的信号传导途径和细胞过程的调节。细胞周期进程或蛋白质稳态的扰动会诱导白色念珠菌丝状化，证明这些过程在形态发生控制中发挥关键作用。细胞周期蛋白依赖性激酶、检查点蛋白、蛋白酶体、热休克蛋白 Hsp90 和热休克转录因子 Hsf1 等调节因子通常通过对细胞周期和蛋白质稳态的相互影响来影响形态发生。这篇综述重点介绍了调节形态发生的主要细胞周期和蛋白质稳态调节因子，并讨论了这两个过程如何交叉以调节这一关键的毒力性状。
Morphological plasticity is a key virulence trait for many fungal pathogens. For the opportunistic fungal pathogen Candida albicans, transitions among yeast, pseudohyphal, and hyphal forms are critical for virulence, because the morphotypes play distinct roles in the infection process. C. albicans morphogenesis is induced in response to many host-relevant conditions and is regulated by complex signaling pathways and cellular processes. Perturbation of either cell-cycle progression or protein homeostasis induces C. albicans filamentation, demonstrating that these processes play a key role in morphogenetic control. Regulators such as cyclin-dependent kinases, checkpoint proteins, the proteasome, the heat shock protein Hsp90, and the heat shock transcription factor Hsf1 all influence morphogenesis, often through interconnected effects on the cell cycle and proteostasis. This review highlights the major cell-cycle and proteostasis regulators that modulate morphogenesis and discusses how these two processes intersect to regulate this key virulence trait.
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