CLEC10A is a prognostic biomarker and correlated with clinical pathologic features and immune infiltrates in lung adenocarcinoma.
CLEC10A is a prognostic biomarker and correlated with clinical pathologic features and immune infiltrates in lung adenocarcinoma.
复制标题
CLEC10A 是一种预后生物标志物，与肺腺癌的临床病理特征和免疫浸润相关
DOI：
10.1111/jcmm.16416
复制
发表时间：
2021-04
影响因子：
5.3
通讯作者：
Zeng S
中科院分区：
文献类型：
--
作者：
He M;Han Y;Cai C;Liu P;Chen Y;Shen H;Xu X;Zeng S
CLEC10A(C型凝集素结构域家族10，成员A)作为C型凝集素受体(CLRs)的成员，在调节先天免疫和获得性免疫方面发挥着重要作用，已显示出作为肿瘤免疫治疗靶点的巨大潜力。然而，目前还没有关于CLEC10A在预测预后风险、免疫治疗或其他治疗肺腺癌(LUAD)方面的功能研究。我们对从TCGA和GEO下载的LUAD数据进行了生物信息学分析，并与HPA、LinkedOmics、Timer、Estiate和TISIDB等在线数据库进行了联合分析。我们发现CLEC10A的低表达伴随着LUAD患者较差的预后。此外，CLEC10A的表达与多种肿瘤浸润性免疫细胞(TIICs)显著相关。CLEC10A作为一种有前景的预后预测指标和潜在的免疫治疗靶点，其对LUAD的潜在影响及其机制值得进一步探讨。
CLEC10A, (C‐type lectin domain family 10, member A), as the member of C‐type lectin receptors (CLRs), plays a vital role in modulating innate immunity and adaptive immunity and has shown great potential as an immunotherapy target for cancers. However, there is no functional research of CLEC10A in prognostic risk, immunotherapy or any other treatment of lung adenocarcinoma (LUAD). We performed bioinformatics analysis on LUAD data downloaded from TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus), and jointly analysed with online databases such as HPA, LinkedOmics, TIMER, ESTIMATE and TISIDB. We found that lower expression of CLEC10A was accompanied with worse outcomes of LUAD patients. Moreover, CLEC10A expression was significantly correlated with a variety of the tumour‐infiltrating immune cells (TIICs). As a promising prognosis predictor and potential immunotherapy target, the potential influence and mechanisms of CLEC10A in LUAD deserve further exploring.
登录
查看更多内容
DOI：
10.1038/nri2569
发表时间：
2009-07
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Geijtenbeek TB;Gringhuis SI
通讯作者：
Gringhuis SI
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
32.4
作者：
Saijo, Shinobu;Ikeda, Satoshi;Iwakura, Yoichiro
通讯作者：
Iwakura, Yoichiro
影响因子：
5.6
作者：
Coombs PJ;Harrison R;Pemberton S;Quintero-Martinez A;Parry S;Haslam SM;Dell A;Taylor ME;Drickamer K
通讯作者：
Drickamer K
影响因子：
2.7
作者：
Modak, S;Koehne, G;Cheung, NKV
通讯作者：
Cheung, NKV