Non-protein coding RNA biomarkers and differential expression in cancers: a review.

Non-protein coding RNA biomarkers and differential expression in cancers: a review.
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DOI:
10.1186/1756-9966-27-19
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发表时间:
2008-07-16
期刊:
Journal of experimental & clinical cancer research : CR
影响因子:
--
通讯作者:
D'Urso OF
D'Urso OF
中科院分区:
其他
文献类型:
--
作者:
Mallardo M;Poltronieri P;D'Urso OF

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近年来,人们发现了大量不编码蛋白质的人类转录本,称为非蛋白质编码RNA。在大多数情况下,小RNA(miRNAs、snoRNAs)和长RNA(反义RNA、dsRNA和长RNA物种)具有多种功能,在转录和转录后水平上调节其他mRNAs,并控制蛋白质的泛素化和降解。不同种类的npcRNAs在不同类型的癌症中有不同的表达。这篇综述讨论了已发表的关于npcRNAs子集表达的数据和新结果。这些结果强调了RNA世界的复杂性,并为功能性RNA参与癌细胞生长控制提供了进一步的证据。
In these years a huge number of human transcripts has been found that do not code for proteins, named non-protein coding RNAs. In most cases, small (miRNAs, snoRNAs) and long RNAs (antisense RNA, dsRNA, and long RNA species) have many roles, functioning as regulators of other mRNAs, at transcriptional and post-transcriptional level, and controlling protein ubiquitination and degradation. Various species of npcRNAs have been found differentially expressed in different types of cancer. This review discusses the published data and new results on the expression of a subset of npcRNAs. These results underscore the complexity of the RNA world and provide further evidence on the involvement of functional RNAs in cancer cell growth control.
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