Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin.
Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin.
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DOI：
10.3390/cells7030017
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发表时间：
2018-03-02
期刊：
影响因子：
6
通讯作者：
Lüscher B
中科院分区：
文献类型：
--
作者：
Bochyńska A;Lüscher-Firzlaff J;Lüscher B
基因表达的调控是通过序列特异性转录调控实现的，它将DNA序列中包含的信息传递到RNA聚合酶活性中。这是通过转录辅助因子的招募来实现的。辅助因子募集的结果之一是控制核小体（染色质的基本单位）及其蛋白质成分（核心组蛋白）的特定性质。其主要原理是调节核小体的位置和特性。后者包括调节核心组蛋白及其整合到核小体中的变体的组成，以及这些组蛋白的翻译后修饰（称为组蛋白标记）。这些标记之一是核心组蛋白H3 （H3K4）赖氨酸4的甲基化。虽然H3K4的单甲基化（H3K4me1）优先位于活性增强子上，但三甲基化（H3K4me3）是在开放和潜在活性启动子上发现的标记。因此，H3K4甲基化通常与基因转录相关。2类赖氨酸甲基转移酶（KMTs）是H3K4甲基化的主要酶。KMT2酶在包含由WDR5、RBBP5、ASH2L和DPY30组成的必要核心复合物中起作用，即所谓的WRAD复合物。在这里，我们讨论了最近的发现，试图阐明KMT2复合物如何被招募到染色质上的特定位点的重要问题。这被嵌入到KMT2复合物的生物学功能和H3K4甲基化的后果的简短概述中。
Regulation of gene expression is achieved by sequence-specific transcriptional regulators, which convey the information that is contained in the sequence of DNA into RNA polymerase activity. This is achieved by the recruitment of transcriptional co-factors. One of the consequences of co-factor recruitment is the control of specific properties of nucleosomes, the basic units of chromatin, and their protein components, the core histones. The main principles are to regulate the position and the characteristics of nucleosomes. The latter includes modulating the composition of core histones and their variants that are integrated into nucleosomes, and the post-translational modification of these histones referred to as histone marks. One of these marks is the methylation of lysine 4 of the core histone H3 (H3K4). While mono-methylation of H3K4 (H3K4me1) is located preferentially at active enhancers, tri-methylation (H3K4me3) is a mark found at open and potentially active promoters. Thus, H3K4 methylation is typically associated with gene transcription. The class 2 lysine methyltransferases (KMTs) are the main enzymes that methylate H3K4. KMT2 enzymes function in complexes that contain a necessary core complex composed of WDR5, RBBP5, ASH2L, and DPY30, the so-called WRAD complex. Here we discuss recent findings that try to elucidate the important question of how KMT2 complexes are recruited to specific sites on chromatin. This is embedded into short overviews of the biological functions of KMT2 complexes and the consequences of H3K4 methylation.
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影响因子：
11.1
作者：
Bonasio R;Shiekhattar R
通讯作者：
Shiekhattar R
影响因子：
3.5
作者：
Alkhatib SG;Landry JW
通讯作者：
Landry JW
影响因子：
4
作者：
Boerdlein, Annegret;Scherthan, Harry;Winterpacht, Andreas
通讯作者：
Winterpacht, Andreas
影响因子：
5.7
作者：
Avdic, Vanja;Zhang, Pamela;Couture, Jean-Francois
通讯作者：
Couture, Jean-Francois
影响因子：
4.6
作者：
Bledau, Anita S.;Schmidt, Kerstin;Anastassiadis, Konstantinos
通讯作者：
Anastassiadis, Konstantinos