Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols.
Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols.
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DOI：
10.1126/sciadv.adh8839
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发表时间：
2023-07-21
期刊：
影响因子：
13.6
通讯作者：
Fisher, Matthew C.
中科院分区：
文献类型：
--
作者：
Shelton, Jennifer M. G.;Rhodes, Johanna;Uzzell, Christopher B.;Hemmings, Samuel;Brackin, Amelie P.;Sewell, Thomas R.;Alghamdi, Asmaa;Dyer, Paul S.;Fraser, Mark;Borman, Andrew M.;Johnson, Elizabeth M.;Piel, Frederic B.;Singer, Andrew C.;Fisher, Matthew C.
使用公民科学的方法，我们确定了一个全国范围内暴露于雾化孢子的人类真菌病原体，烟曲霉菌，已获得耐药性的农业杀菌剂戊唑醇和一线唑类临床抗真菌药物。基因组分析表明，在环境和患者中发现的耐药基因型之间没有区别，表明至少40%的唑类耐药A。烟曲霉感染是通过环境暴露获得的。热点和冷点的气溶胶化唑类耐药孢子是不稳定的季节性采样期间之间。这表明大气混合程度很高，导致人均累积年接触量估计为21天（±2.6天）。由于这种测量暴露的普遍性，我们必须确定耐唑A的来源。减少曲霉病患者治疗失败。公民科学表明，广泛暴露于雾化真菌孢子，已演变为对临床药物的耐药性。
Using a citizen science approach, we identify a country-wide exposure to aerosolized spores of a human fungal pathogen, Aspergillus fumigatus, that has acquired resistance to the agricultural fungicide tebuconazole and first-line azole clinical antifungal drugs. Genomic analysis shows no distinction between resistant genotypes found in the environment and in patients, indicating that at least 40% of azole-resistant A. fumigatus infections are acquired from environmental exposures. Hotspots and coldspots of aerosolized azole-resistant spores were not stable between seasonal sampling periods. This suggests a high degree of atmospheric mixing resulting in an estimated per capita cumulative annual exposure of 21 days (±2.6). Because of the ubiquity of this measured exposure, it is imperative that we determine sources of azole-resistant A. fumigatus to reduce treatment failure in patients with aspergillosis. Citizen science shows widespread exposure to aerosolized fungal spores that have evolved resistance to clinical drugs.
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