MicroRNAs as biomarkers in solid organ transplantation.
MicroRNAs as biomarkers in solid organ transplantation.
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DOI：
10.1111/j.1600-6143.2012.04313.x
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Maluf DG
中科院分区：
文献类型：
--
作者：
Mas VR;Dumur CI;Scian MJ;Gehrau RC;Maluf DG
在改善实体器官移植的短期结果方面取得了重要进展。然而，在过去几十年中，长期结果并没有改善。迫切需要供体质量的生物标志物，移植物损伤的早期诊断和治疗反应。MicroRNA（miRNAs）是一类通过翻译抑制特定靶mRNA发挥功能的小单链非编码RNA。miRNA的表达与不同的疾病和生理条件有关。此外，已经在不同的生物流体中检测到miRNA，并且这些循环miRNA可以区分患病个体和健康对照。循环miRNA检测的非侵入性性质、其疾病特异性以及用于检测和监测这些分子的准确技术的可用性鼓励了对miRNA生物标志物研究的追求以及对移植领域中的特定应用的评估。miRNA表达可能成为同种异体移植物损伤和功能的良好生物标志物。在这篇小综述中，我们总结了最近发表的报告的主要成就，重点是确定miRNA作为器官质量，缺血再灌注损伤，急性排斥反应，耐受和慢性同种异体移植功能障碍的生物标志物，强调其机制和临床潜在的应用，并描述其方法的局限性。
Important progress has been made in improving short term outcomes in solid organ transplantation. However, long-term outcomes have not improved during the last decades. There is a critical need for biomarkers of donor quality, early diagnosis of graft injury and treatment response. MicroRNAs (miRNAs) are a class of small single stranded noncoding RNAs that function through translational repression of specific target mRNAs. MiRNA expression has been associated with different diseases and physiological conditions. Moreover, miRNAs have been detected in different biological fluids and these circulating miRNAs can distinguish diseased individuals from healthy controls. The noninvasive nature of circulating miRNA detection, their disease specificity, and the availability of accurate techniques for detecting and monitoring these molecules has encouraged a pursuit of miRNA biomarker research and the evaluation of specific applications in the transplant field. miRNA expression might develop as excellent biomarkers of allograft injury and function. In this minireview, we summarize the main accomplishments of recently published reports focused on the identification of miRNAs as biomarkers in organ quality, ischemia-reperfusion injury, acute rejection, tolerance and chronic allograft dysfunction emphasizing their mechanistic and clinical potential applications and describing their methodological limitations.
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影响因子：
5.1
作者：
Mas VR;Mueller TF;Archer KJ;Maluf DG
通讯作者：
Maluf DG
影响因子：
4.6
作者：
Farid, Waqar R. R.;Pan, Qiuwei;van der Laan, Luc J. W.
通讯作者：
van der Laan, Luc J. W.
影响因子：
4.4
作者：
Buermans HP;Ariyurek Y;van Ommen G;den Dunnen JT;'t Hoen PA
通讯作者：
't Hoen PA
DOI：
10.1073/pnas.0813121106
发表时间：
2009-03-31
影响因子：
11.1
作者：
Anglicheau, Dany;Sharma, Vijay K.;Suthanthiran, Manikkam
通讯作者：
Suthanthiran, Manikkam
影响因子：
4.8
作者：
Korpal, Manav;Lee, Esther S.;Kang, Yibin
通讯作者：
Kang, Yibin