Stress responses in the opportunistic pathogen Acinetobacter baumannii.
Stress responses in the opportunistic pathogen Acinetobacter baumannii.
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DOI：
10.2217/fmb.12.150
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发表时间：
2013-03
影响因子：
3.1
通讯作者：
Actis LA
中科院分区：
文献类型：
--
作者：
Fiester SE;Actis LA
鲍曼不动杆菌在全世界范围内引起广泛的严重感染。这些感染的相关性部分是由于这种病原体感知环境和宿主应激信号并对其作出反应的能力，使其能够在医疗环境和人类宿主中持续存在和传播。本文综述了环境和细胞应激因素在A.鲍曼不动杆菌抵抗营养剥夺、氧化和亚硝化损伤，甚至抵抗常用的防腐剂乙醇的存在，乙醇可以作为营养和毒性增强信号，而不仅仅是方便的消毒剂。新出现的实验证据支持这些反应在感染A的发病机制中的作用。鲍曼不动杆菌在人类中的致病性及其抵抗抗生素和宿主反应效应物的能力。
Acinetobacter baumannii causes a wide range of severe infections among compromised and injured patients worldwide. The relevance of these infections are, in part, due to the ability of this pathogen to sense and react to environmental and host stress signals, allowing it to persist and disseminate in medical settings and the human host. This review summarizes current knowledge on the roles that environmental and cellular stressors play in the ability of A. baumannii to resist nutrient deprivation, oxidative and nitrosative injury, and even the presence of the commonly used antiseptic ethanol, which could serve as a nutrient- and virulence-enhancing signal rather than just being a convenient disinfectant. Emerging experimental evidence supports the role of some of these responses in the pathogenesis of the infections A. baumannii causes in humans and its capacity to resist antibiotics and host response effectors.
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影响因子：
3.4
作者：
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通讯作者：
Lee, JC
影响因子：
3.1
作者：
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