Omega-3 Fatty Acids and PPARgamma in Cancer.
Omega-3 Fatty Acids and PPARgamma in Cancer.
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DOI：
10.1155/2008/358052
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发表时间：
2008
期刊：
影响因子：
2.9
通讯作者：
O'Flaherty JT
中科院分区：
文献类型：
--
作者：
Edwards IJ;O'Flaherty JT
Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural ligands for peroxisome proliferator receptor activator (PPAR)γ and, due to the effects of PPARγ on cell proliferation, survival, and differentiation, are potential anticancer agents. Dietary intake of omega-3 PUFAs has been associated with a reduced risk of certain cancers in human populations and in animal models. In vitro studies have shown that omega-3 PUFAs inhibit cell proliferation and induce apoptosis in cancer cells through various pathways but one of which involves PPARγ activation. The differential activation of PPARγ and PPARγ-regulated genes by specific dietary fatty acids may be central to their distinct roles in cancer. This review summarizes studies relating PUFAs to PPARγ and cancer and offers a new paradigm relating an n-3 PUFA through PPARγ to the expression of the cell surface proteoglycan, syndecan-1, and to the death of cancer cells.
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.1
作者：
Allred, CD;Kilgore, MW
通讯作者：
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影响因子：
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作者：
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通讯作者：
Freeman, BA
DOI：
10.1124/jpet.104.079079
发表时间：
2005-04-01
影响因子：
3.5
作者：
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通讯作者：
Powell, WS