Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS).
Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS).
复制标题
DOI：
10.1136/thoraxjnl-2014-206680
复制
发表时间：
2015-07
期刊：
影响因子：
10
通讯作者：
Thickett DR
中科院分区：
文献类型：
--
作者：
Dancer RC;Parekh D;Lax S;D'Souza V;Zheng S;Bassford CR;Park D;Bartis DG;Mahida R;Turner AM;Sapey E;Wei W;Naidu B;Stewart PM;Fraser WD;Christopher KB;Cooper MS;Gao F;Sansom DM;Martineau AR;Perkins GD;Thickett DR
维生素 D 缺乏被认为是败血症和强化治疗单位死亡率的致病因素，但尚未被评估为急性呼吸窘迫综合征 (ARDS) 的危险因素。这些关联的因果关系从未得到证实。确定临床环境中 ARDS 是否与维生素 D 缺乏相关，并确定 ARDS 实验模型中维生素 D 缺乏是否会影响其严重程度。本研究包括人类、小鼠和体外原代肺泡上皮细胞工作。维生素 D 缺乏（血浆 25(OH)D 水平<50nmol/L）在 ARDS 患者中普遍存在，并且存在于绝大多数食管切除术后有发生 ARDS 风险的患者中。在气管内脂多糖挑战的小鼠模型中，饮食引起的维生素 D 缺乏导致严重的肺泡炎症、上皮损伤和缺氧。在体外，维生素 D 对影响超过 600 个基因的原代人肺泡上皮细胞具有营养作用。在临床环境中，在食管切除术之前通过药物补充维生素 D 可以减少维生素 D 缺乏患者体内肺泡毛细血管损伤测量值的变化。维生素 D 缺乏症在急性呼吸窘迫综合征 (ARDS) 患者中很常见。维生素 D 缺乏似乎会导致病情发展，因此应开发纠正有 ARDS 风险的患者维生素 D 缺乏的方法。 UKCRN ID 11994。
Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these associations has never been demonstrated. To determine if ARDS is associated with vitamin D deficiency in a clinical setting and to determine if vitamin D deficiency in experimental models of ARDS influences its severity. Human, murine and in vitro primary alveolar epithelial cell work were included in this study. Vitamin D deficiency (plasma 25(OH)D levels <50 nmol/L) was ubiquitous in patients with ARDS and present in the vast majority of patients at risk of developing ARDS following oesophagectomy. In a murine model of intratracheal lipopolysaccharide challenge, dietary-induced vitamin D deficiency resulted in exaggerated alveolar inflammation, epithelial damage and hypoxia. In vitro, vitamin D has trophic effects on primary human alveolar epithelial cells affecting >600 genes. In a clinical setting, pharmacological repletion of vitamin D prior to oesophagectomy reduced the observed changes of in vivo measurements of alveolar capillary damage seen in deficient patients. Vitamin D deficiency is common in people who develop ARDS. This deficiency of vitamin D appears to contribute to the development of the condition, and approaches to correct vitamin D deficiency in patients at risk of ARDS should be developed. UKCRN ID 11994.
登录
查看更多内容
影响因子：
10
作者：
Perkins, G. D.;Gao, F.;Thickett, D. R.
通讯作者：
Thickett, D. R.
影响因子：
2
作者：
Mohamed, W. A. Wahab;Al-Shehri, M. A.
通讯作者：
Al-Shehri, M. A.
影响因子：
6.9
作者：
Leow, Leong;Simpson, Talia;Hancox, Robert J.
通讯作者：
Hancox, Robert J.
影响因子：
10
作者：
Calfee, C. S.;Ware, L. B.;Matthay, M. A.
通讯作者：
Matthay, M. A.
影响因子：
7
作者：
Hewison, Martin
通讯作者：
Hewison, Martin