Renal dysfunction in patients with thalassaemia.
Renal dysfunction in patients with thalassaemia.
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DOI：
10.1111/j.1365-2141.2010.08477.x
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发表时间：
2011-04
影响因子：
6.5
通讯作者：
Thalassemia Clinical Research Network
中科院分区：
文献类型：
--
作者：
Quinn CT;Johnson VL;Kim HY;Trachtenberg F;Vogiatzi MG;Kwiatkowski JL;Neufeld EJ;Fung E;Oliveri N;Kirby M;Giardina PJ;Thalassemia Clinical Research Network
地中海贫血对肾脏的影响知之甚少。地中海贫血患者潜在肾功能异常的特征是及时的，因为较新的铁螯合剂地拉罗司可能具有肾毒性。我们的目的是确定地拉罗司广泛应用前接受治疗的地中海贫血患者中肾脏异常的患病率和相关性，使用24小时尿液收集。我们计算肌酐清除率和尿钙/肌酐比值，并测量尿β2-微球蛋白、白蛋白和蛋白质。我们使用多变量模型来确定肾功能不全的临床、治疗和实验室预测因素。三分之一没有定期输血的地中海贫血患者肌酐清除率异常高。定期输血与清除率下降相关（P = 0.004）。几乎三分之一的地中海贫血患者有高钙尿症，定期输血与高钙尿症的频率和程度增加有关（P <0.0001）。超过一半的患者出现白蛋白尿，但与输血治疗并不一致。总之，肾超滤、高钙尿和蛋白尿在地中海贫血中很常见。较高的输血强度与较低的肌酐清除率相关，但更频繁的高钙尿症。输血的效果需要更好地理解。地中海贫血患者潜在肾功能不全的意识可以告知现在关于铁螯合的使用和监测的决定。
Little is known about the effects of thalassaemia on the kidney. Characterization of underlying renal function abnormalities in thalassaemia is timely because the newer iron chelator, deferasirox, can be nephrotoxic. We aimed to determine the prevalence and correlates of renal abnormalities in thalassaemia patients, treated before deferasirox was widely available, using 24-h collections of urine. We calculated creatinine clearance and urine calcium-to-creatinine ratio and measured urinary β2-microglobulin, albumin, and protein. We used multivariate modelling to identify clinical, therapeutic, and laboratory predictors of renal dysfunction. One-third of thalassaemia patients who were not regularly transfused had abnormally high creatinine clearance. Regular transfusions were associated with a decrease in clearance (P = 0·004). Almost one-third of patients with thalassaemia had hypercalciuria, and regular transfusions were associated with an increase in the frequency and degree of hypercalciuria (P < 0·0001). Albuminuria was found in over half of patients, but was not consistently associated with transfusion therapy. In summary, renal hyperfiltration, hypercalciuria, and albuminuria are common in thalassaemia. Higher transfusion intensity is associated with lower creatinine clearance but more frequent hypercalciuria. The transfusion effect needs to be better understood. Awareness of underlying renal dysfunction in thalassaemia can inform decisions now about the use and monitoring of iron chelation.
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影响因子：
19.6
作者：
CIANCIULLI, P;SOLLECITO, D;CARTA, S
通讯作者：
CARTA, S
DOI：
10.1001/archpedi.1989.02150210113029
发表时间：
1989-09-01
影响因子：
--
作者：
KOREN, G;BENTUR, Y;FREEDMAN, MH
通讯作者：
FREEDMAN, MH
thalalsyaine骨骼疾病：一个频繁且仍未解决的问题。
DOI：
10.1359/jbmr.080505
发表时间：
2009-03
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Vogiatzi MG;Macklin EA;Fung EB;Cheung AM;Vichinsky E;Olivieri N;Kirby M;Kwiatkowski JL;Cunningham M;Holm IA;Lane J;Schneider R;Fleisher M;Grady RW;Peterson CC;Giardina PJ;Thalassemia Clinical Research Network
通讯作者：
Thalassemia Clinical Research Network
影响因子：
2.5
作者：
MASTRANGELO, F;LOPEZ, T;ALFONSO, L
通讯作者：
ALFONSO, L
影响因子：
3
作者：
Sumboonnanonda, A;Malasit, P;Vongjirad, A
通讯作者：
Vongjirad, A