Role of Notch signaling in colon homeostasis and carcinogenesis.
Role of Notch signaling in colon homeostasis and carcinogenesis.
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DOI：
10.1111/j.1349-7006.2011.02049.x
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发表时间：
2011-11
期刊：
影响因子：
5.7
通讯作者：
Rosenberg DW
中科院分区：
文献类型：
--
作者：
Miyamoto S;Rosenberg DW
Colorectal cancer (CRC) is a leading cause of cancer-related deaths world-wide. Despite the development of new anti-cancer agents, there will be an estimated 150,000 new cases and 50,000 deaths associated with this disease during the next year. This is due in part to the limitations of chemotherapy resulting from drug resistance and organ system toxicities. To overcome the inherent limitations associated with standard chemotherapy modalities, the development of novel drug targets is of utmost importance in combating this disease. There is accumulating evidence that a small fraction of cancer cells, referred to as cancer stem cells, may play a critical role in the pathogenesis of this disease. In fact, the identification of cancer stem cells can be accomplished based on the expression of surface markers associated with a cancer stem-like phenotype. This stem-like phenotype includes indefinite self-replication, pluripotency, and most importantly, resistance to chemotherapeutics. Therefore, understanding the properties of cancer stem cells may ultimately lead to new therapeutic approaches. Recently, several studies have shown that Notch signaling is critical to maintain the cancer stem cell properties. This review provides summary of colonic crypt organization and colon carcinogenesis from the point of view of stem cells. Moreover, we discuss novel therapeutic strategies that are under development for targeting Notch signaling in cancer stem cells.
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