Social interaction following prepubertal stress alters prefrontal gene expression associated with cell signalling and oligodendrocytes.
Social interaction following prepubertal stress alters prefrontal gene expression associated with cell signalling and oligodendrocytes.
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青春期前压力后的社交互动改变了与细胞信号传导和少突胶质细胞相关的前额叶基因表达。
DOI：
10.1038/s41398-022-02280-7
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发表时间：
2022-12-16
影响因子：
6.8
通讯作者：
Brydges, Nichola M.
中科院分区：
文献类型：
--
作者：
Moon, Anna L.;Clifton, Nicholas E.;Wellard, Natalie;Thomas, Kerrie L.;Hall, Jeremy;Brydges, Nichola M.
早年生活中的逆境与以后生活中精神病理（包括情绪障碍）的风险增加有关。早期生活压力影响几个生理系统，然而，病理风险的确切机制尚不完全清楚。这一知识对于制定适当的治疗干预措施至关重要。青春期前是前额叶皮层（PFC）成熟的关键发育时期，前额叶皮层是涉及高级认知功能（包括社会功能）的大脑区域。在这项研究中，我们对经历过青春期前应激（PPS）的成年大鼠和对照组的PFC进行了RNA测序，以研究这种应激的全基因组后果。PPS会改变成年后的社会行为，因此我们在社会互动测试后对PPS和对照大鼠进行了RNA测序，以确定社会活动依赖基因的变化。在基线状态（社会互动测试后1周），PPS组中没有基因差异表达。然而，在社交互动后，PPS大鼠与对照组相比，有1603个基因的表达存在差异。这些基因在与细胞信号传导和轴突髓鞘形成动力学相关的生物学途径中富集。细胞富集分析表明，这些基因与少突胶质细胞相关，与现有早期生活压力测序数据集的比较表明，与少突胶质细胞形态相关的途径在一系列啮齿动物早期生活压力模型中受到影响。综上所述，我们确定了一些通路，包括与轴突髓鞘形成有关的那些通路，它们在PPS后的社会刺激反应中在成人中被不同地激活。这些不同的反应可能导致精神病理的易感性。
Early-life adversity is associated with an increased risk of psychopathology, including mood disorders, later in life. Early-life stress affects several physiological systems, however, the exact mechanisms underlying pathological risk are not fully understood. This knowledge is crucial in developing appropriate therapeutic interventions. The prepubertal period is documented as a key developmental period for the maturation of the prefrontal cortex (PFC), a brain region involved in higher cognitive functions, including social function. In this study, we performed RNA sequencing on the PFC of adult rats who had experienced prepubertal stress (PPS) and controls to investigate the genome-wide consequences of this stress. PPS alters social behaviour in adulthood, therefore we also performed RNA sequencing on PPS and control rats following a social interaction test to determine social activity-dependent gene changes. At a baseline state (1 week following a social interaction test), no genes were differentially expressed in the PPS group. However, 1603 genes were differentially expressed in PPS rats compared to controls following a social interaction. These genes were enriched in biological pathways associated with cell signalling and axon myelination dynamics. Cell enrichment analysis showed these genes were associated with oligodendrocytes, and a comparison with an existing early-life stress sequencing dataset showed that pathways linked to oligodendrocyte morphology are impacted in a range of models of early-life stress in rodents. In conclusion, we identify pathways, including those involved in axon myelination, that are differentially activated in the adult in response to social stimulation following PPS. These differential responses may contribute to vulnerability to psychiatric pathology.
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影响因子：
5.8
作者：
Barnett, Derek W.;Garrison, Erik K.;Marth, Gabor T.
通讯作者：
Marth, Gabor T.
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
11
作者：
Clifton NE;Rees E;Holmans PA;Pardiñas AF;Harwood JC;Di Florio A;Kirov G;Walters JTR;O'Donovan MC;Owen MJ;Hall J;Pocklington AJ
通讯作者：
Pocklington AJ
影响因子：
4.7
作者：
Cassiers LLM;Sabbe BGC;Schmaal L;Veltman DJ;Penninx BWJH;Van Den Eede F
通讯作者：
Van Den Eede F
与压力有关的精神疾病的性别差异：神经生物学观点。
影响因子：
7.4
作者：
Bangasser, Debra A.;Valentino, Rita J.
通讯作者：
Valentino, Rita J.