Biomimetic and Materials-Potentiated Cell Engineering for Cancer Immunotherapy.

Biomimetic and Materials-Potentiated Cell Engineering for Cancer Immunotherapy.
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用于癌症免疫治疗的仿生和材料增强细胞工程

DOI:
10.3390/pharmaceutics14040734
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发表时间:
2022-03-29
期刊:
影响因子:
5.4
通讯作者:
Li, Yongyong
Li, Yongyong
中科院分区:
医学2区
文献类型:
--
作者:
Zhang, Tingting;Yang, Yushan;Huang, Li;Liu, Ying;Chong, Gaowei;Yin, Weimin;Dong, Haiqing;Li, Yan;Li, Yongyong

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在癌症免疫治疗中,免疫细胞是根除肿瘤的主力军。然而,由于肿瘤免疫抑制微环境的驯化,它们似乎功能失调。最近,许多材料工程策略被提出以增强免疫细胞的抗肿瘤效果。这些策略要么利用仿生材料作为构建模块来构建功能类似于天然活细胞的无生命实体,要么用功能材料改造免疫细胞以增强其抗肿瘤效果。在这篇综述中,我们将总结不同细胞类型中的这些先进策略,并讨论该领域的前景。
In cancer immunotherapy, immune cells are the main force for tumor eradication. However, they appear to be dysfunctional due to the taming of the tumor immunosuppressive microenvironment. Recently, many materials-engineered strategies are proposed to enhance the anti-tumor effect of immune cells. These strategies either utilize biomimetic materials, as building blocks to construct inanimate entities whose functions are similar to natural living cells, or engineer immune cells with functional materials, to potentiate their anti-tumor effects. In this review, we will summarize these advanced strategies in different cell types, as well as discussing the prospects of this field.
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