Neutrophil-inspired propulsion in a combined acoustic and magnetic field.
Neutrophil-inspired propulsion in a combined acoustic and magnetic field.
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DOI：
10.1038/s41467-017-00845-5
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发表时间：
2017-10-03
影响因子：
16.6
通讯作者：
Nelson BJ
中科院分区：
文献类型：
--
作者：
Ahmed D;Baasch T;Blondel N;Läubli N;Dual J;Nelson BJ
能够在脉管系统中精确运动的系统可以为靶向治疗和非侵入性手术中的应用提供令人兴奋的可能性。到目前为止，大多数的工作分析推进在一个二维的设置有限的可控性附近的边界。在这里，我们通过在磁场和声场中引入超顺磁性粒子来展示生物启发的滚动运动，灵感来自于中性粒细胞在墙上滚动。在旋转磁场的存在下，由于偶极-偶极相互作用，粒子自组装。由于声场的辐射力，聚集体朝向通道的壁迁移。通过结合这两个领域，我们实现了滚动型运动沿着边界。声场和磁场的使用在临床环境中已经成熟。这两种场的组合能够克服单致动技术所遇到的限制。我们相信我们的方法将在靶向治疗方面产生深远的影响。在微环境中设计有效的游泳和推进策略对于药物递送应用是有吸引力的。在这里，Ahmed等人展示了一种微推进策略，其中磁场和声场的组合用于沿着通道壁组装和推进胶体颗粒。
Systems capable of precise motion in the vasculature can offer exciting possibilities for applications in targeted therapeutics and non-invasive surgery. So far, the majority of the work analysed propulsion in a two-dimensional setting with limited controllability near boundaries. Here we show bio-inspired rolling motion by introducing superparamagnetic particles in magnetic and acoustic fields, inspired by a neutrophil rolling on a wall. The particles self-assemble due to dipole–dipole interaction in the presence of a rotating magnetic field. The aggregate migrates towards the wall of the channel due to the radiation force of an acoustic field. By combining both fields, we achieved a rolling-type motion along the boundaries. The use of both acoustic and magnetic fields has matured in clinical settings. The combination of both fields is capable of overcoming the limitations encountered by single actuation techniques. We believe our method will have far-reaching implications in targeted therapeutics. Devising effective swimming and propulsion strategies in microenvironments is attractive for drug delivery applications. Here Ahmed et al. demonstrate a micropropulsion strategy in which a combination of magnetic and acoustic fields is used to assemble and propel colloidal particles along channel walls.
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影响因子：
6.1
作者：
Ahmed, Daniel;Mao, Xiaole;Huang, Tony Jun
通讯作者：
Huang, Tony Jun
影响因子：
2.8
作者：
Ahmed, Daniel;Mao, Xiaole;Huang, Tony Jun
通讯作者：
Huang, Tony Jun
DOI：
10.1073/pnas.1413325111
发表时间：
2014-09-09
影响因子：
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作者：
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通讯作者：
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影响因子：
8.7
作者：
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通讯作者：
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影响因子：
4.6
作者：
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通讯作者：
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