Cardiovascular disease risk factors in chronic kidney disease: A systematic review and meta-analysis.
Cardiovascular disease risk factors in chronic kidney disease: A systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0192895
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Gray LJ
中科院分区：
文献类型：
--
作者：
Major RW;Cheng MRI;Grant RA;Shantikumar S;Xu G;Oozeerally I;Brunskill NJ;Gray LJ
慢性肾脏病（CKD）是一种全球性的健康负担，与心血管疾病风险增加独立相关。在临床实践中，使用基于常规收集的风险因素的预后模型评估一般人群的心血管风险。在CKD中，由于传统动脉粥样硬化和非传统风险因素的相互作用，预后模型可能错误地表示风险。本系统评价的目的是确定常规收集的风险因素，以纳入CKD特异性心血管预后模型。观察性队列研究和随机对照试验的系统综述和荟萃分析。使用预定义和注册方案（PROSPERO ID-2016：CRD 42016036187）从MEDLINE和Embase检索中识别的研究。主要入选标准为年龄≥18岁的非终末期CKD患者。收集的风险因素中，提取了已确定的心血管风险因素的多变量调整。主要结局为致死性和非致死性心血管事件。对3，232篇摘要的审查确定了29个常规收集的风险因素，其中20个在1个以上队列中列出。确定了21个队列，涉及27，465人和100，838人年。除了传统的一般人群心血管危险因素外，左心室肥大、血清白蛋白、磷酸盐、尿酸盐和血红蛋白与未来心血管事件的相关性均具有统计学意义。这些非传统的危险因素应该在未来的心血管预后模型的发展中进行评估，用于CKD患者。
Chronic kidney disease (CKD) is a global health burden and is independently associated with increased cardiovascular disease risk. Assessment of cardiovascular risk in the general population using prognostic models based on routinely collected risk factors is embedded in clinical practice. In CKD, prognostic models may misrepresent risk due to the interplay of traditional atherosclerotic and non-traditional risk factors. This systematic review’s aim was to identify routinely collected risk factors for inclusion in a CKD-specific cardiovascular prognostic model. Systematic review and meta-analysis of observational cohort studies and randomized controlled trials. Studies identified from MEDLINE and Embase searches using a pre-defined and registered protocol (PROSPERO ID—2016:CRD42016036187). The main inclusion criteria were individuals ≥18 years of age with non-endstage CKD. Routinely collected risk factors where multi-variable adjustment for established cardiovascular risk factors had occurred were extracted. The primary outcome was fatal and non-fatal cardiovascular events. The review of 3,232, abstracts identified 29 routinely collected risk factors of which 20 were presented in more than 1 cohort. 21 cohorts were identified in relation to 27,465 individuals and 100,838 person-years. In addition to established traditional general population cardiovascular risk factors, left ventricular hypertrophy, serum albumin, phosphate, urate and hemoglobin were all found to be statistically significant in their association with future cardiovascular events. These non-traditional risk factors should be assessed in the development of future cardiovascular prognostic models for use in individuals with CKD.
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DOI：
10.1136/bmj.f5680
发表时间：
2013-10-03
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Blood Pressure Lowering Treatment Trialists' Collaboration;Ninomiya T;Perkovic V;Turnbull F;Neal B;Barzi F;Cass A;Baigent C;Chalmers J;Li N;Woodward M;MacMahon S
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MacMahon S
影响因子：
6.1
作者：
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通讯作者：
Saran, Rajiv
影响因子：
24
作者：
De Nicola, Luca;Gabbai, Francis B.;Minutolo, Roberto
通讯作者：
Minutolo, Roberto
影响因子：
2.3
作者：
Locatelli, Francesco;Eckardt, Kai-Uwe;Drueeke, Tilman B.
通讯作者：
Drueeke, Tilman B.
DOI：
10.2215/cjn.02350213
发表时间：
2013-11-07
影响因子：
9.8
作者：
Chen, Szu-Chia;Hung, Chi-Chih;Chen, Hung-Chun
通讯作者：
Chen, Hung-Chun