The role of forkhead box Q1 transcription factor in ovarian epithelial carcinomas.
The role of forkhead box Q1 transcription factor in ovarian epithelial carcinomas.
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DOI：
10.3390/ijms131113881
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发表时间：
2012-10-26
影响因子：
5.6
通讯作者：
Wang TL
中科院分区：
文献类型：
--
作者：
Gao M;Shih IeM;Wang TL
The role of the forkhead box Q1 (FOXQ1) transcription factor in cancer pathogenesis has recently emerged. Overexpression of FOXQ1 has been found in a variety of human cancers, and its upregulation has been associated with poor prognosis in colorectal, breast, and non-small cell lung carcinomas. However, the molecular mechanism underlying how FOXQ1 contributes to ovarian epithelial carcinomas remains unclear. To this end, we analyzed gene expression levels in ovarian cancer tissues and cell lines and demonstrated a higher expression level of FOXQ1 in epithelial ovarian cancer cells than that in normal epithelial cells. We then used a human ovarian cancer cell line, SKOV3, which expressed a higher level of FOXQ1, as a cell model to investigate the biological effects of FOXQ1 by using RNA interference. Silencing of FOXQ1 expression using a shRNA knockdown approach affected the expression of several cell cycle regulators, leading to suppressed cell proliferation, reduced cell motility/invasion, and upregulation of epithelial cell markers and the downregulation of mesenchymal cell markers. Taken together, these results suggest that FOXQ1 expression is essential to maintain cell proliferation, motility/invasion, and epithelial-mesenchymal transition phenotypes in ovarian cancer cells.
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DOI：
10.1097/pas.0b013e3181cf3d79
发表时间：
2010-03
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Kurman RJ;Shih IeM
通讯作者：
Shih IeM
影响因子：
11.5
作者：
Marquez, RT;Baggerly, KA;Lu, KH
通讯作者：
Lu, KH
影响因子：
11.2
作者：
Zhang H;Meng F;Liu G;Zhang B;Zhu J;Wu F;Ethier SP;Miller F;Wu G
通讯作者：
Wu G
影响因子：
11.2
作者：
Qiao, Yuanyuan;Jiang, Xia;Yu, Qiang
通讯作者：
Yu, Qiang
影响因子：
3.1
作者：
Bieller, A;Pasche, B;Zoll, B
通讯作者：
Zoll, B