Preliminary Exploration of Pseudo-CT-Based Attenuation Correction for Simultaneous PET/MRI Brain Imaging in Nonhuman Primates.
Preliminary Exploration of Pseudo-CT-Based Attenuation Correction for Simultaneous PET/MRI Brain Imaging in Nonhuman Primates.
复制标题
DOI：
10.1021/acsomega.3c04824
复制
发表时间：
2023-12-05
期刊：
影响因子：
4.1
通讯作者：
Wey, Hsiao-Ying
中科院分区：
文献类型：
--
作者：
Yoo, Chi-Hyeon;DuBois, Jonathan M.;Wang, Lu;Tang, Yongjin;Hou, Lu;Xu, Hao;Chen, Jiahui;Liang, Steven H.;Izquierdo-Garcia, David;Wey, Hsiao-Ying
This study aimed to develop a template-based attenuation correction (AC) for the nonhuman primate (NHP) brain. We evaluated the effects of AC on positron emission tomography (PET) data quantification with two experimental paradigms by comparing the quantitative outcomes obtained using a segmentation-based AC versus template-based AC. Population-based atlas was generated from ten adult rhesus macaques. Bolus experiments using [18F]PF-06455943 and a bolus-infusion experiment using [11C]OMAR were performed on a 3T Siemens PET/magnetic resonance-imaging (MRI). PET data were reconstructed with either μ map obtained from the segmentation-based AC or template-based AC. The standard uptake value (SUV), volume of distribution (VT), or percentage occupancy of rimonabant were calculated for [18F]PF-06455943 and [11C]OMAR PET, respectively. The leave-one-out cross-validation showed that the absolute percentage differences were 2.54 ± 2.86% for all region of interests. The segmentation-based AC had a lower SUV and VT (∼10%) of [18F]PF-06455943 than the template-based method. The estimated occupancy was higher in the template-based method compared to the segmentation-based AC in the bolus-infusion study. However, future studies may be needed if a different reference tissue is selected for data quantification. Our template-based AC approach was successfully developed and applied to the NHP brain. One limitation of this study was that validation was performed by comparing two different MR-based AC approaches without validating against AC methods based on computed tomography (CT).
登录
查看更多内容
影响因子：
3.5
作者：
Rohlfing T;Kroenke CD;Sullivan EV;Dubach MF;Bowden DM;Grant KA;Pfefferbaum A
通讯作者：
Pfefferbaum A
影响因子：
5.7
作者：
Villien M;Wey HY;Mandeville JB;Catana C;Polimeni JR;Sander CY;Zürcher NR;Chonde DB;Fowler JS;Rosen BR;Hooker JM
通讯作者：
Hooker JM
DOI：
10.1007/s00259-002-0796-3
发表时间：
2002-07-01
影响因子：
9.1
作者：
Burger, C;Goerres, G;von Schulthess, GK
通讯作者：
von Schulthess, GK
影响因子：
2.5
作者：
ZHANG, YP;SHI, LM
通讯作者：
SHI, LM
PET/MRI扫描仪进行多中心脑成像研究的资格途径：使用患者幻影评估基于MRI的衰减校正方法。
DOI：
10.2967/jnumed.120.261881
发表时间：
2022-04
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Catana C;Laforest R;An H;Boada F;Cao T;Faul D;Jakoby B;Jansen FP;Kemp BJ;Kinahan PE;Larson P;Levine MA;Maniawski P;Mawlawi O;McConathy JE;McMillan AB;Price JC;Rajagopal A;Sunderland J;Veit-Haibach P;Wangerin KA;Ying C;Hope TA
通讯作者：
Hope TA