First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation.
First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation.
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DOI：
10.1016/j.athoracsur.2010.02.036
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发表时间：
2010-05
影响因子：
4.6
通讯作者：
Ratcliffe, Mark B.
中科院分区：
文献类型：
--
作者：
Wenk, Jonathan F.;Zhang, Zhihong;Cheng, Guangming;Malhotra, Deepak;Acevedo-Bolton, Gabriel;Burger, Mike;Suzuki, Takamaro;Saloner, David A.;Wallace, Arthur W.;Guccione, Julius M.;Ratcliffe, Mark B.
后基底部心肌梗死后左室重构可导致缺血性二尖瓣返流。这是由于后乳头肌移位导致瓣叶拴系的结果。左心室，二尖瓣装置，腱索的有限元模型创建磁共振图像从羊中度二尖瓣返流后基底部心肌梗死。该模型的每个区域的特征在于一个特定的本构关系，捕获的材料响应时，受到生理压力负荷。模型模拟在后瓣叶和前瓣叶之间产生间隙，刚好在梗死后乳头肌上方，这表明二尖瓣返流。当梗塞区域的硬度降低时，这会导致壁扩张，小叶之间的差距面积增加33%。此外，瓣叶中的应力在靠近差距的腱索连接点周围增加。在这项工作中概述的方法将允许使用非侵入性技术生成左心室和二尖瓣的有限元模型。
Left ventricular remodeling after postero-basal myocardial infarction can lead to ischemic mitral regurgitation. This occurs as a consequence of leaflet tethering due to posterior papillary muscle displacement. A finite element model of the left ventricle, mitral apparatus, and chordae tendineae was created from magnetic resonance images from a sheep that developed moderate mitral regurgitation after postero-basal myocardial infarction. Each region of the model was characterized by a specific constitutive law that captured the material response when subjected to physiological pressure loading. The model simulation produced a gap between the posterior and anterior leaflets, just above the infarcted posterior papillary muscle, which is indicative of mitral regurgitation. When the stiffness of the infarct region was reduced, this caused the wall to distend and the gap area between the leaflets to increase by 33%. Additionally, the stress in the leaflets increased around the chordal connection points near the gap. The methodology outlined in this work will allow a finite element model of both the left ventricle and mitral valve to be generated using non-invasive techniques.
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