Mitochondrial quality control in health and cardiovascular diseases.
Mitochondrial quality control in health and cardiovascular diseases.
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DOI：
10.3389/fcell.2023.1290046
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发表时间：
2023
影响因子：
5.5
通讯作者：
Noval Rivas, Magali
中科院分区：
文献类型：
--
作者：
Atici, Asli E.;Crother, Timothy R.;Noval Rivas, Magali
心血管疾病是世界范围内死亡的主要原因之一。最佳的线粒体功能是供应高能量需求的组织的核心，例如心血管系统。除了产生ATP作为能量来源外，线粒体还在很大程度上参与了对环境压力的适应和组织功能的微调。线粒体质量控制(MQC)通过分裂、融合、有丝分裂和生物发生来确保心血管组织中功能失调的线粒体的清除和维持线粒体的动态平衡。此外，线粒体产生活性氧物种(ROS)，从而触发促炎细胞因子的产生，并调节细胞生存。线粒体功能障碍与多种心血管疾病有关，包括缺血再灌注(I/R)、动脉粥样硬化、心力衰竭、心肌肥厚、高血压、糖尿病和遗传性心肌病以及川崎病(KD)。因此，MQC在促进心血管健康方面起着关键作用。在这里，我们概述了MQC的机制，并讨论了目前关于心血管疾病线粒体适应的文献。
Cardiovascular diseases (CVDs) are one of the primary causes of mortality worldwide. An optimal mitochondrial function is central to supplying tissues with high energy demand, such as the cardiovascular system. In addition to producing ATP as a power source, mitochondria are also heavily involved in adaptation to environmental stress and fine-tuning tissue functions. Mitochondrial quality control (MQC) through fission, fusion, mitophagy, and biogenesis ensures the clearance of dysfunctional mitochondria and preserves mitochondrial homeostasis in cardiovascular tissues. Furthermore, mitochondria generate reactive oxygen species (ROS), which trigger the production of pro-inflammatory cytokines and regulate cell survival. Mitochondrial dysfunction has been implicated in multiple CVDs, including ischemia-reperfusion (I/R), atherosclerosis, heart failure, cardiac hypertrophy, hypertension, diabetic and genetic cardiomyopathies, and Kawasaki Disease (KD). Thus, MQC is pivotal in promoting cardiovascular health. Here, we outline the mechanisms of MQC and discuss the current literature on mitochondrial adaptation in CVDs.
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影响因子：
5.9
作者：
Brahimi-Horn MC;Giuliano S;Saland E;Lacas-Gervais S;Sheiko T;Pelletier J;Bourget I;Bost F;Féral C;Boulter E;Tauc M;Ivan M;Garmy-Susini B;Popa A;Mari B;Sarry JE;Craigen WJ;Pouysségur J;Mazure NM
通讯作者：
Mazure NM
影响因子：
17.1
作者：
Acin-Perez, Rebeca;Victoria Lechuga-Vieco, Ana;Antonio Enriquez, Jose
通讯作者：
Antonio Enriquez, Jose
影响因子：
5.1
作者：
Anzell AR;Maizy R;Przyklenk K;Sanderson TH
通讯作者：
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影响因子：
64.8
作者：
Baughman, Joshua M.;Perocchi, Fabiana;Girgis, Hany S.;Plovanich, Molly;Belcher-Timme, Casey A.;Sancak, Yasemin;Bao, X. Robert;Strittmatter, Laura;Goldberger, Olga;Bogorad, Roman L.;Koteliansky, Victor;Mootha, Vamsi K.
通讯作者：
Mootha, Vamsi K.
影响因子：
29
作者：
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通讯作者：
Langer, Thomas