No Evidence for Enhancement of Spatial Ability with Elevated Prenatal Androgen Exposure in Congenital Adrenal Hyperplasia: A Meta-Analysis.
No Evidence for Enhancement of Spatial Ability with Elevated Prenatal Androgen Exposure in Congenital Adrenal Hyperplasia: A Meta-Analysis.
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DOI：
10.1007/s10508-020-01645-7
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发表时间：
2020-03
影响因子：
3.8
通讯作者：
Hines M
中科院分区：
文献类型：
--
作者：
Collaer ML;Hines M
空间能力有助于生活和职业能力，某些空间技能平均而言在男性和女性之间存在差异，当出现差异时，通常有利于男性。有助于空间技能的因素可能包括产前以及经验/文化影响，生物和社会影响可能相互作用，难以解开。本荟萃分析通过对先天性肾上腺皮质增生（CAH）患者的研究，探讨了产前雄激素暴露对空间技能的潜在影响。CAH涉及产前肾上腺雄激素升高，CAH女性患者的总体雄激素浓度高于同性对照组，但CAH男性患者与对照组之间的总体差异不大。我们假设，如果雄激素有助于产前神经行为发育在人类在许多其他物种，女性CAH将显示空间增强与对照组女性，但没有明确的假设男性。12项研究的荟萃分析，检查整体空间技能和三个空间亚类未能支持增强的空间表现与CAH女性，男性CAH显示较低的空间能力相比，控制男性，至少在整体空间技能的类别。虽然统计学逻辑排除了接受女性的零假设，但荟萃分析未能支持产前暴露于雄激素解释人类空间性别/性别差异的观点。在某些空间任务中的平均性别/性别差异的其他解释可能包括雄激素暴露在其他时间，如青春期，或男性和女性经历的不同社会因素。我们还讨论了CAH女性与男性不同结局的可能解释。
Spatial abilities contribute to life and occupational competencies, and certain spatial skills differ, on average, between males and females, typically favoring males when differences occur. Factors contributing to spatial skills could include prenatal as well as experiential/cultural influences, with biological and social influences likely interacting and difficult to disentangle. This meta-analysis examined the potential influence of prenatal androgen exposure on spatial skill by examining studies of patients with congenital adrenal hyperplasia (CAH). CAH involves elevated adrenal androgens prenatally, with overall androgen concentrations higher for females with CAH vs. same-sex controls but with little overall difference between males with CAH versus controls. We hypothesized that, if androgens contribute prenatally to neurobehavioral development in humans as in many other species, females with CAH would show spatial enhancement versus control females, but with no definitive hypothesis for males. Meta-analysis of 12 studies examining overall spatial skill and three spatial subcategories failed to support enhanced spatial performance for females with CAH; males with CAH showed lower spatial ability compared to control males, at least for the category of overall spatial skill. Although statistical logic precludes accepting the null hypothesis for females, the meta-analysis failed to support the idea that prenatal exposure to androgens explains spatial gender/sex differences in humans. Alternative explanations for average gender/sex differences in some spatial tasks could include androgen exposure at other times, such as mini-puberty, or different social factors experienced by males and females. We also discuss possible explanations for the different outcomes seen in females vs. males with CAH.
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影响因子：
3.7
作者：
Collaer ML;Hindmarsh PC;Pasterski V;Fane BA;Hines M
通讯作者：
Hines M
影响因子：
3.7
作者：
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Tweedie, R
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通讯作者：
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影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
3.7
作者：
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通讯作者：
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