Long-Lasting Cognitive Abnormalities after COVID-19.
Long-Lasting Cognitive Abnormalities after COVID-19.
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DOI：
10.3390/brainsci11020235
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发表时间：
2021-02-13
期刊：
影响因子：
3.3
通讯作者：
Priori A
中科院分区：
文献类型：
--
作者：
Ferrucci R;Dini M;Groppo E;Rosci C;Reitano MR;Bai F;Poletti B;Brugnera A;Silani V;D'Arminio Monforte A;Priori A
考虑到新冠肺炎中能够导致脑变化的机制，我们旨在研究出院后几个月认知异常的发生。我们招募了38名(年龄22-74岁；27名男性)因SARS-CoV-2感染并发症而在非重症COVID病房住院的患者。参与者在出院后大约5个月接受了神经心理测试。在所有患者中，42.1%的患者存在加工速度缺陷，而26.3%的患者表现出延迟的语言回忆缺陷。21%的人在处理速度和言语记忆方面都存在缺陷。双因素分析显示，入院时最低动脉血氧分压(PaO2)与吸入氧分压(FiO2)(P/F)与言语记忆巩固成绩呈正相关(r=0.404，p=0.027)，入院时SpO2水平与延迟言语回忆成绩(sRT-D得分，rs=0.373，p=0.042)呈正相关。住院期间发生的急性呼吸窘迫综合征与无急性呼吸窘迫综合征的患者相比，言语记忆能力较差(分别为30.63±13.33vs.44.5±13.16vs.44.5±13.16vs.8.10±2.62，p=0.029)。新冠肺炎患者出院5个月后常可发现认知功能异常。出院几个月后，疲劳感增加，注意力和记忆力下降，认知速度总体下降，都会干扰工作和日常活动。
Considering the mechanisms capable of causing brain alterations in COVID-19, we aimed to study the occurrence of cognitive abnormalities in the months following hospital discharge. We recruited 38 (aged 22–74 years; 27 males) patients hospitalized for complications of SARS-CoV-2 infection in nonintensive COVID units. Participants underwent neuropsychological testing about 5 months after hospital discharge. Of all patients, 42.1% had processing speed deficits, while 26.3% showed delayed verbal recall deficits. Twenty-one percent presented with deficits in both processing speed and verbal memory. Bivariate analysis revealed a positive correlation between the lowest arterial oxygen partial pressure (PaO2) to fractional inspired oxygen (FiO2) (P/F) ratio during hospitalization and verbal memory consolidation performance (SRT-LTS score, r = 0.404, p = 0.027), as well as a positive correlation between SpO2 levels upon hospital arrival and delayed verbal recall performance (SRT-D score, rs = 0.373, p = 0.042). Acute respiratory distress syndrome (ARDS) during hospitalization was associated with worse verbal memory performance (ARDS vs. no ARDS: SRT-LTS mean score = 30.63 ± 13.33 vs. 44.50 ± 13.16, p = 0.007; SRT-D mean score = 5.95 ± 2.56 vs. 8.10 ± 2.62, p = 0.029). Cognitive abnormalities can frequently be found in COVID-19 patients 5 months after hospital discharge. Increased fatigability, deficits of concentration and memory, and overall decreased cognitive speed months after hospital discharge can interfere with work and daily activities.
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DOI：
10.1016/s0232-1513(11)80067-8
发表时间：
1991-01-01
期刊：
EXPERIMENTAL PATHOLOGY
影响因子：
--
作者：
CERVOSNAVARRO, J;SAMPAOLO, S;HAMDORF, G
通讯作者：
HAMDORF, G
影响因子：
7.3
作者：
Hamming, I;Timens, W;van Goor, H
通讯作者：
van Goor, H
影响因子：
7.5
作者：
Klok, F. A.;Kruip, M. J. H. A.;Endeman, H.
通讯作者：
Endeman, H.
DOI：
10.1177/1352458506070933
发表时间：
2006-12-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Amato, M. P.;Portaccio, E.;Trojano, M.
通讯作者：
Trojano, M.
DOI：
10.1164/ajrccm.160.1.9708059
发表时间：
1999-07-01
影响因子：
24.7
作者：
Hopkins, RO;Weaver, LK;Larson-Lohr, V
通讯作者：
Larson-Lohr, V