Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis.
Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis.
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DOI：
10.3390/nu13114103
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发表时间：
2021-11-16
期刊：
影响因子：
5.9
通讯作者：
Morrison CD
中科院分区：
文献类型：
--
作者：
Khan MS;Spann RA;Münzberg H;Yu S;Albaugh VL;He Y;Berthoud HR;Morrison CD
摄食行为受多种相互竞争的生理需求的指导，因为动物必须感知其内部营养状态，然后识别并食用满足营养需求的食物。膳食蛋白质摄入是提供必需氨基酸所必需的，代表了一种特定的、独特的营养需求。与这种重要性相一致的是，有相当多的文献表明，蛋白质的摄入是有道理的，这样动物就能感觉到蛋白质的限制，并适应性地改变摄食行为以增加蛋白质的摄入。在这里，我们认为，这种匹配的食物消费与生理需要至少需要两个并行的机制：第一个是检测内部的营养需求（蛋白质的需要状态），第二个是不同的营养成分之间的食物的歧视。在这篇综述中，我们概述了各种机制，可以介导的需要状态的感觉和蛋白质丰富和蛋白质缺乏的食物之间的歧视。最后，我们简要地描述了这些机制的相互作用如何使动物能够在一系列复杂的食物之间进行自我选择，以满足营养需求，并适应性地应对外部环境或内部生理状态的变化。
Feeding behavior is guided by multiple competing physiological needs, as animals must sense their internal nutritional state and then identify and consume foods that meet nutritional needs. Dietary protein intake is necessary to provide essential amino acids and represents a specific, distinct nutritional need. Consistent with this importance, there is a relatively strong body of literature indicating that protein intake is defended, such that animals sense the restriction of protein and adaptively alter feeding behavior to increase protein intake. Here, we argue that this matching of food consumption with physiological need requires at least two concurrent mechanisms: the first being the detection of internal nutritional need (a protein need state) and the second being the discrimination between foods with differing nutritional compositions. In this review, we outline various mechanisms that could mediate the sensing of need state and the discrimination between protein-rich and protein-poor foods. Finally, we briefly describe how the interaction of these mechanisms might allow an animal to self-select between a complex array of foods to meet nutritional needs and adaptively respond to changes in either the external environment or internal physiological state.
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影响因子：
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