Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology.
Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology.
复制标题
DOI：
10.1007/s12576-017-0556-6
复制
发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Watanabe M
中科院分区：
文献类型：
--
作者：
Takai A;Eto M;Hirano K;Takeya K;Wakimoto T;Watanabe M
蛋白磷酸酶1和2 A(PP1和PP2A)是真核细胞中分布最广泛、含量最丰富的丝氨酸/苏氨酸磷酸酶。它们在各种细胞功能的调节中起着重要作用。本文就近年来这些酶在平滑肌生理学领域的功能研究进展作一综述。许多天然存在的具有不同相对PP1/PP2A亲和力的蛋白磷酸酶抑制剂已被发现，并被广泛用作强大的研究工具。介绍和讨论了PP1/PP2A抑制剂的化学生物学研究现状，重点介绍了在海洋海绵共生微生物中鉴定的与Calyculin A生物合成有关的基因簇。
Protein phosphatases 1 and 2A (PP1 and PP2A) are the most ubiquitous and abundant serine/threonine phosphatases in eukaryotic cells. They play fundamental roles in the regulation of various cellular functions. This review focuses on recent advances in the functional studies of these enzymes in the field of smooth muscle physiology. Many naturally occurring protein phosphatase inhibitors with different relative PP1/PP2A affinities have been discovered and are widely used as powerful research tools. Current topics in the chemical biology of PP1/PP2A inhibitors are introduced and discussed, highlighting the identification of the gene cluster responsible for the biosynthesis of calyculin A in a symbiont microorganism of a marine sponge.
登录
查看更多内容
影响因子：
4.8
作者：
Favre, B;Turowski, P;Hemmings, BA
通讯作者：
Hemmings, BA
影响因子：
11.2
作者：
Cho, Hyun-Soo;Suzuki, Takehiro;Hamamoto, Ryuji
通讯作者：
Hamamoto, Ryuji
影响因子：
1.8
作者：
DESILVA, ED;WILLIAMS, DE;ALLEN, TM
通讯作者：
ALLEN, TM
影响因子：
5.5
作者：
Gao, Ning;Chang, Audrey N.;Stull, James T.
通讯作者：
Stull, James T.
影响因子：
5.5
作者：
BIALOJAN, C;RUEGG, JC;TAKAI, A
通讯作者：
TAKAI, A