The Effect of Wolbachia on Genetic Divergence between Populations: Models with Two‐Way Migration
The Effect of Wolbachia on Genetic Divergence between Populations: Models with Two‐Way Migration
复制标题
沃尔巴克氏体对种群间遗传分化的影响：双向迁移模型
DOI：
10.1086/342153
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
J. Werren
中科院分区：
文献类型：
--
作者：
A. Telschow;P. Hammerstein;J. Werren
沃尔巴克氏体是细胞内细菌，在其宿主中引起各种生殖改变，包括细胞质不相容性（CI），精子和卵子之间的不相容性，通常导致胚胎死亡。我们从理论上研究了沃尔巴克氏体诱导的双向CI对两个种群之间分歧水平的影响，其中存在两个方向的迁移和单个位点的差异选择。主要发现如下：两个种群中的沃尔巴克氏体差异维持到阈值迁移率，高于阈值迁移率，系统崩溃为单一的沃尔巴克氏体类型;核位点的差异选择增加阈值迁移率，低于阈值迁移率，沃尔巴克氏体多态性得以维持;种群之间的沃尔巴克氏体差异通过降低“有效迁移率，即使是中等水平的CI也会导致等位基因频率的巨大群体差异;与无沃尔巴克氏体的情况相比，不对称CI会导致有效迁移率的强烈不对称，并显着改变遗传分化的模式。我们推导出一个有效迁移率的解析近似，这与大多数参数值的模拟结果相匹配。这些结果基本上支持CI Wolbachia可能导致种群间遗传分化的观点。
Wolbachia are intracellular bacteria that cause various reproduction alterations in their hosts, including cytoplasmic incompatibility (CI), an incompatibility between sperm and egg that typically results in embryonic death. We investigate theoretically the effects of Wolbachia‐induced bidirectional CI on levels of divergence between two populations, where there is migration in both directions and differential selection at a single locus. The main findings are as follows: Wolbachia differences in the two populations are maintained up to a threshold migration rate, above which the system collapses to a single Wolbachia type; differential selection at a nuclear locus increases the threshold migration rate below which Wolbachia polymorphisms are maintained; Wolbachia differences between the populations enhance their genetic divergence at the selected locus by reducing the “effective migration rate,” and even moderate levels of CI can cause large population differences in allele frequencies; and asymmetric CI can induce strong asymmetries in effective migration rate and dramatically alter the pattern of genetic divergence compared with the No Wolbachia situation. We derive an analytical approximation for the effective migration rate, which matches the simulation results for most parameter values. These results generally support the view that CI Wolbachia can contribute to genetic divergence between populations.
差异垂直传播下的共生体存活和宿主-共生体不平衡。
影响因子：
3.3
作者：
Sánchez,MS;Arnold,J;Asmussen,MA
通讯作者：
Asmussen,MA