Symbiont survival and host-symbiont disequilibria under differential vertical transmission.

Symbiont survival and host-symbiont disequilibria under differential vertical transmission.
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差异垂直传播下的共生体存活和宿主-共生体不平衡。

DOI:
10.1093/genetics/154.3.1347
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发表时间:
2000
期刊:
影响因子:
3.3
通讯作者:
Asmussen,MA
Asmussen,MA
中科院分区:
生物学2区
文献类型:
--
作者:
Sánchez,MS;Arnold,J;Asmussen,MA

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宿主-共生体系统中种间遗传相互作用提出了有趣的共同进化问题,并可能影响公共卫生和管理政策的有效性。在这里,我们提出了一个分析和数值调查的影响宿主遗传异质性的共生体的垂直传播率。我们考虑的基线情况下,一个单态共生体和一个单一的双等位基因位点在其二倍体主机,垂直传输是唯一的力量。我们的分析引入种间不平衡来量化宿主基因型和等位基因与共生体存在/不存在之间的非随机关联。的瞬态和平衡的行为进行检查,随机生成的初始条件和传输参数的模拟。与宿主基因型之间垂直传播率均匀的情况相比,差异传播(i)将共生体的平均生存率从50%提高到近60%,(ii)将共生体生存的最低平均传播率从0.5显着降低到0.008,(iii)很容易造成永久性的宿主-共生体从头不平衡,而均匀传输既不能创建也不能维持这种关联。平均而言,杂合子在种群中携带和维持共生体的可能性略高,并且与共生体的关联更随机。结果表明,简单的进化力量可以在两个物种之间创造大量的非随机关联。
Interspecific genetic interactions in host-symbiont systems raise intriguing coevolutionary questions and may influence the effectiveness of public health and management policies. Here we present an analytical and numerical investigation of the effects of host genetic heterogeneity in the rate of vertical transmission of a symbiont. We consider the baseline case with a monomorphic symbiont and a single diallelic locus in its diploid host, where vertical transmission is the sole force. Our analysis introduces interspecific disequilibria to quantify nonrandom associations between host genotypes and alleles and symbiont presence/absence. The transient and equilibrium behavior is examined in simulations with randomly generated initial conditions and transmission parameters. Compared to the case where vertical transmission rates are uniform across host genotypes, differential transmission (i) increases average symbiont survival from 50% to almost 60%, (ii) dramatically reduces the minimum average transmission rate for symbiont survival from 0.5 to 0.008, and (iii) readily creates permanent host-symbiont disequilibria de novo, whereas uniform transmission can neither create nor maintain such associations. On average, heterozygotes are slightly more likely to carry and maintain the symbiont in the population and are more randomly associated with the symbiont. Results show that simple evolutionary forces can create substantial nonrandom associations between two species.
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