Molecular interactions of proteins and peptides at interfaces studied by sum frequency generation vibrational spectroscopy.
Molecular interactions of proteins and peptides at interfaces studied by sum frequency generation vibrational spectroscopy.
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DOI：
10.1021/la203823t
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发表时间：
2012-01-31
期刊：
影响因子：
--
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Liu Y;Jasensky J;Chen Z
界面多肽和蛋白质在许多生物过程中都是至关重要的，因此引起了各个研究领域的兴趣。为了研究这些过程，需要表面敏感技术来完整地描述许多复杂过程所固有的不同界面相互作用。和频发生(SFG)光谱已发展成为研究各种界面多肽和蛋白质之间相互作用及其机制的有力工具。结果表明，SFG具有固有的表面敏感性，能够获得这些体系的构象、取向和有序性信息。本文综述了近年来关于多肽/蛋白质-底物相互作用、多肽/蛋白质-膜相互作用和蛋白质界面复合体的研究进展，并展示了SFG揭示复杂界面生物过程的分子图像的能力。
Interfacial peptides and proteins are critical in many biological processes and thus are of interest to various research fields. To study these processes, surface sensitive techniques are required to completely describe different interfacial interactions intrinsic to many complicated processes. Sum frequency generation (SFG) spectroscopy has been developed into a powerful tool to investigate these interactions and mechanisms of a variety of interfacial peptides and proteins. It has been shown that SFG has intrinsic surface sensitivity and the ability to acquire conformation, orientation and ordering information about these systems. This paper reviews recent studies on peptide/protein-substrate interactions, peptide/protein-membrane interactions and protein complexes at interfaces and demonstrates the ability of SFG on unveiling the molecular pictures of complicated interfacial biological processes.
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影响因子：
15
作者：
Chen, Xiaoyun;Boughton, Andrew P.;Chen, Zhan
通讯作者：
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作者：
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影响因子：
3.9
作者：
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影响因子：
3.9
作者：
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通讯作者：
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影响因子：
27.1
作者：
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通讯作者：
Chen Z