HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties.
HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties.
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DOI:
10.3389/fmicb.2014.00398
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发表时间:
2014
影响因子:
5.2
通讯作者:
Romanelli MG
中科院分区:
文献类型:
--
作者:
Ciminale V;Rende F;Bertazzoni U;Romanelli MG
HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes. Differences in the kinetics of viral mRNA expression, functional properties of the regulatory and accessory proteins, and interactions with cellular factors and signal transduction pathways are discussed.
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DOI:
10.1073/pnas.88.13.5704
发表时间:
1991-07-01
影响因子:
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通讯作者:
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通讯作者:
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