Repetitive tactile stimulation changes resting-state functional connectivity-implications for treatment of sensorimotor decline.
Repetitive tactile stimulation changes resting-state functional connectivity-implications for treatment of sensorimotor decline.
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DOI：
10.3389/fnhum.2012.00144
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发表时间：
2012
影响因子：
2.9
通讯作者：
Ritter P
中科院分区：
文献类型：
--
作者：
Freyer F;Reinacher M;Nolte G;Dinse HR;Ritter P
神经紊乱和生理老化会导致知觉能力下降。与传统的强化训练和练习的治疗方法不同，被动重复感觉刺激(RSS)作为一种在不需要主动参与的情况下提高感知能力来对抗感觉衰退的替代方法，近年来得到了越来越多的关注。一种特别有效的高频RSS，利用Hebbian学习原理，提高了感知敏锐度和感觉运动功能，并已成功地应用于治疗慢性中风患者和老年受试者。高频RSS可诱导体感皮层的可塑性变化，如代表性地图重组，但其对大脑正在进行的网络活动和静息状态功能连接的影响尚未被研究。在这里，我们将高频RSS应用于健康受试者，并通过假想相干(Imcoh)分析RSS前后的静息状态脑电(EEG)功能连接模式。ImCoh是一种特定频率的连接性测量，已知可以减少由于体积传导和共同参考引起的过度估计偏差。30分钟的被动高频RSS可引起分布于感觉和运动皮质区域的个体上α频段静息状态节律的显著改变。这些刺激引起的分布式功能连通性改变可能是先前观察到的感觉运动整合改善的基础。
Neurological disorders and physiological aging can lead to a decline of perceptual abilities. In contrast to the conventional therapeutic approach that comprises intensive training and practicing, passive repetitive sensory stimulation (RSS) has recently gained increasing attention as an alternative to countervail the sensory decline by improving perceptual abilities without the need of active participation. A particularly effective type of high-frequency RSS, utilizing Hebbian learning principles, improves perceptual acuity as well as sensorimotor functions and has been successfully applied to treat chronic stroke patients and elderly subjects. High-frequency RSS has been shown to induce plastic changes of somatosensory cortex such as representational map reorganization, but its impact on the brain's ongoing network activity and resting-state functional connectivity has not been investigated so far. Here, we applied high-frequency RSS in healthy human subjects and analyzed resting state Electroencephalography (EEG) functional connectivity patterns before and after RSS by means of imaginary coherency (ImCoh), a frequency-specific connectivity measure which is known to reduce over-estimation biases due to volume conduction and common reference. Thirty minutes of passive high-frequency RSS lead to significant ImCoh-changes of the resting state mu-rhythm in the individual upper alpha frequency band within distributed sensory and motor cortical areas. These stimulation induced distributed functional connectivity changes likely underlie the previously observed improvement in sensorimotor integration.
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影响因子：
5.3
作者：
Becker, Robert;Reinacher, Matthias;Ritter, Petra
通讯作者：
Ritter, Petra
影响因子：
5.7
作者：
Hanslmayr, Simon;Aslan, Alp;Baeuml, Karl-Heinz
通讯作者：
Baeuml, Karl-Heinz
影响因子：
5.7
作者：
Freyer, Frank;Becker, Robert;Ritter, Petra
通讯作者：
Ritter, Petra
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
9.2
作者：
Beste, Christian;Wascher, Edmund;Dinse, Hubert R.
通讯作者：
Dinse, Hubert R.