The changing tide of human fertility.
The changing tide of human fertility.
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DOI：
10.1093/humrep/deac011
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发表时间：
2022-04-01
期刊：
影响因子：
--
通讯作者：
Aitken RJ
中科院分区：
文献类型：
--
作者：
Aitken RJ
在过去半个世纪里，世界上几乎每个国家的生育率都急剧下降。生育率的普遍下降主要是由于社会因素的调解，其中最有力的是妇女的教育以及随之而来的生活目的从生育的转变。此外，很明显，环境和生活方式因素也对我们的生殖能力产生了深远的影响，特别是在男性中，日益繁荣与睾丸癌发病率的显着上升以及精液质量和睾丸激素水平的长期下降有关。在另一个时间尺度上，我们还应该认识到，与人口结构转型相关的繁荣程度提高，通过降低婴儿和儿童死亡率，大大降低了对高生育率基因的选择压力。人类人口中生育力差的基因的保留也因ART的增加而加剧。所有这些因素都在合谋将我们的物种推入不育陷阱，这是可以理解的。如果我们要避免后者，就必须认识到造成这一现象的因素，并采取必要的社会、政治、环境和生活方式变革，以控制这一局势。
Over the past half-century, the world has witnessed a steep decline in fertility rates in virtually every country on Earth. This universal decline in fertility is being driven by increasing prosperity largely through the mediation of social factors, the most powerful of which are the education of women and an accompanying shift in life’s purpose away from procreation. In addition, it is clear that environmental and lifestyle factors are also having a profound impact on our reproductive competence particularly in the male where increasing prosperity is associated with a significant rise in the incidence of testicular cancer and a secular decline in semen quality and testosterone levels. On a different timescale, we should also recognize that the increased prosperity associated with the demographic transition greatly reduces the selection pressure on high fertility genes by lowering the rates of infant and childhood mortality. The retention of poor fertility genes within the human population is also being exacerbated by the increased uptake of ART. It is arguable that all of these elements are colluding to drive our species into an infertility trap. If we are to avoid the latter, it will be important to recognize the factors contributing to this phenomenon and adopt the social, political, environmental and lifestyle changes needed to bring this situation under control.
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影响因子：
6.1
作者：
Ferreux, Lucile;Bourdon, Mathilde;Patrat, Catherine
通讯作者：
Patrat, Catherine
影响因子：
6.1
作者：
Chang, Wei-Hsiang;Li, Sih-Syuan;Lee, Ching-Chang
通讯作者：
Lee, Ching-Chang
影响因子：
6.1
作者：
Belva, F.;Bonduelle, M.;Keymolen, K.
通讯作者：
Keymolen, K.
影响因子：
5.2
作者：
Aitken RJ;Baker MA
通讯作者：
Baker MA
影响因子：
4.4
作者：
Chodick, Gabriel;Epstein, Shdema;Shalev, Varda
通讯作者：
Shalev, Varda