Maximum likelihood estimation for the proportional odds model with mixed interval-censored failure time data.
Maximum likelihood estimation for the proportional odds model with mixed interval-censored failure time data.
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DOI：
10.1080/02664763.2020.1789077
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发表时间：
2020
影响因子：
1.5
通讯作者：
Hudson MM
中科院分区：
文献类型：
--
作者：
Zhu L;Tong X;Cai D;Li Y;Sun R;Srivastava DK;Hudson MM
本文讨论了混合间隔截尾失效时间数据的回归分析。这些数据经常出现在各种环境中，包括临床试验、流行病学调查和许多其他具有随访成分的生物医学研究。例如，混合失败时间通常在儿童癌症后长期生存的两项最大研究中发现，这些数据集激发了这项工作。然而，大多数现有的失效时间数据方法只考虑正确审查或仅间隔审查的失效时间，而不是时间可能混合的更一般的情况。此外，在混合间隔截短失效时间的回归模型中，通常采用比例风险公式。众所周知，在某些情况下，比例风险模型可能是不合适的，在这种情况下，需要替代方法来分析混合失效时间数据。为了满足这一需求，我们开发了一个混合区间截尾数据的比例赔率回归模型的最大似然估计程序。我们证明了所得到的估计量是一致且渐近高斯的。为了评估该方法的有限样本特性，进行了广泛的仿真研究，研究表明，该方法在许多实际情况下都能很好地工作。然后，我们应用我们的方法来检查年龄对儿童癌症长期幸存者中生长激素缺乏风险的影响。
This article discusses regression analysis of mixed interval-censored failure time data. Such data frequently occur across a variety of settings, including clinical trials, epidemiologic investigations, and many other biomedical studies with a follow-up component. For example, mixed failure times are commonly found in the two largest studies of long-term survivorship after childhood cancer, the datasets that motivated this work. However, most existing methods for failure time data consider only right-censored or only interval-censored failure times, not the more general case where times may be mixed. Additionally, among regression models developed for mixed interval-censored failure times, the proportional hazards formulation is generally assumed. It is well-known that the proportional hazards model may be inappropriate in certain situations, and alternatives are needed to analyze mixed failure time data in such cases. To fill this need, we develop a maximum likelihood estimation procedure for the proportional odds regression model with mixed interval-censored data. We show that the resulting estimators are consistent and asymptotically Gaussian. An extensive simulation study is performed to assess the finite-sample properties of the method, and this investigation indicates that the proposed method works well for many practical situations. We then apply our approach to examine the impact of age at cranial radiation therapy on risk of growth hormone deficiency in long-term survivors of childhood cancer.
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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DOI：
10.1198/016214504000001420
发表时间：
2005-06-01
影响因子：
3.7
作者：
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通讯作者：
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影响因子：
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作者：
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