Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike.
Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike.
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DOI：
10.1016/j.xcrm.2020.100126
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发表时间：
2020-10-20
期刊：
影响因子：
--
通讯作者：
Finzi A
中科院分区：
文献类型：
--
作者：
Prévost J;Gasser R;Beaudoin-Bussières G;Richard J;Duerr R;Laumaea A;Anand SP;Goyette G;Benlarbi M;Ding S;Medjahed H;Lewin A;Perreault J;Tremblay T;Gendron-Lepage G;Gauthier N;Carrier M;Marcoux D;Piché A;Lavoie M;Benoit A;Loungnarath V;Brochu G;Haddad E;Stacey HD;Miller MS;Desforges M;Talbot PJ;Maule GTG;Côté M;Therrien C;Serhir B;Bazin R;Roger M;Finzi A
SARS-CoV-2是2019年冠状病毒病（COVID-19）大流行的罪魁祸首，感染了数百万人，并造成数十万人死亡。SARS-CoV-2的刺突糖蛋白介导病毒进入，并且是中和抗体的主要靶标。了解针对SARS-CoV-2的抗体反应对于疫苗，治疗和公共卫生干预措施的发展至关重要。在这里，我们对106名SARS-CoV-2感染者进行了一项横断面研究，以评估SARS-CoV-2 Spike的体液反应。大多数感染个体在症状发作的2周内引发抗刺突抗体。受体结合域（RBD）特异性免疫球蛋白G（IgG）的水平随时间持续存在，抗RBD IgM的水平在症状消退后下降。虽然大多数人在感染后2周内产生中和抗体，但中和活性水平会随着时间的推移而显著降低。我们的研究结果强调了研究自然SARS-CoV-2感染后中和活性持续性的重要性。针对SARS-CoV-2的抗体与COVID-19的严重程度相关，在感染后2周内，RBD特异性IgM和伊加的下降速度比IgG SARS-CoV-2中和抗体的下降速度更快。报告了一项对106名COVID-19患者的横断面研究，并显示大多数感染者能够随着时间的推移引发持续的抗体反应。然而，血浆中和能力减弱感染解决后，但其对保护免受再感染的影响仍然未知。
SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The Spike glycoproteins of SARS-CoV-2 mediate viral entry and are the main targets for neutralizing antibodies. Understanding the antibody response directed against SARS-CoV-2 is crucial for the development of vaccine, therapeutic, and public health interventions. Here, we perform a cross-sectional study on 106 SARS-CoV-2-infected individuals to evaluate humoral responses against SARS-CoV-2 Spike. Most infected individuals elicit anti-Spike antibodies within 2 weeks of the onset of symptoms. The levels of receptor binding domain (RBD)-specific immunoglobulin G (IgG) persist over time, and the levels of anti-RBD IgM decrease after symptom resolution. Although most individuals develop neutralizing antibodies within 2 weeks of infection, the level of neutralizing activity is significantly decreased over time. Our results highlight the importance of studying the persistence of neutralizing activity upon natural SARS-CoV-2 infection. Antibodies against SARS-CoV-2 Spike correlate with COVID-19 severity RBD-specific IgM and IgA decline more rapidly than IgG SARS-CoV-2 neutralizing antibodies are elicited within 2 weeks of infection Neutralizing antibodies decline significantly after resolution of the infection Prévost et al. report a cross-sectional study on a cohort of 106 COVID-19 patients and show that most infected individuals are able to elicit a sustained antibody response over time. However, plasma neutralizing capacity wanes after infection resolution, but its implication on protection from re-infection remains unknown.
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IGA主导对SARS-COV-2的早期中和抗体反应。
影响因子：
17.1
作者：
Sterlin D;Mathian A;Miyara M;Mohr A;Anna F;Claër L;Quentric P;Fadlallah J;Devilliers H;Ghillani P;Gunn C;Hockett R;Mudumba S;Guihot A;Luyt CE;Mayaux J;Beurton A;Fourati S;Bruel T;Schwartz O;Lacorte JM;Yssel H;Parizot C;Dorgham K;Charneau P;Amoura Z;Gorochov G
通讯作者：
Gorochov G
影响因子：
5.4
作者：
Desforges, Marc;Desjardins, Jessica;Talbot, Pierre J.
通讯作者：
Talbot, Pierre J.
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
影响因子：
15.8
作者：
ter Meulen, Jan;van den Brink, Edward N.;Poon, Leo L. M.;Marissen, Wilfred E.;Leung, Cynthia S. W.;Cox, Freek;Cheung, Chung Y.;Bakker, Arjen Q.;Bogaards, Johannes A.;van Deventer, Els;Preiser, Wolfgang;Doerr, Hans Wilhelm;Chow, Vincent T.;de Kruif, John;Peiris, Joseph S. M.;Goudsmit, Jaap
通讯作者：
Goudsmit, Jaap
影响因子：
19
作者：
Haveri, Anu;Smura, Teemu;Savolainen-Kopra, Carita
通讯作者：
Savolainen-Kopra, Carita