Myocardial remodeling: cellular and extracellular events and targets.
Myocardial remodeling: cellular and extracellular events and targets.
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DOI：
10.1146/annurev-physiol-012110-142230
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发表时间：
2011
影响因子：
18.2
通讯作者：
Spinale FG
中科院分区：
文献类型：
--
作者：
Dixon JA;Spinale FG
本综述的重点是利用大型动物模型和临床研究，提供基本的洞察细胞和细胞外途径有助于心肌梗死（MI）后左心室（LV）重构的翻译研究。具体而言，大动物和临床研究都检查了内源性和外源性干细胞改变LV重塑过程的潜在作用。有趣的是，尽管缺乏长期的细胞植入，但干细胞治疗的LV重塑发生了变化。将干细胞治疗的全部潜力转化为临床研究还有待实现。还检查了有助于MI后重塑过程的蛋白水解途径的调节。基于最近的大动物研究，MI后的干细胞治疗与蛋白水解途径的改变之间似乎存在关系，从而产生了干细胞留下了缓和LV重塑的回声效应的假设。
The focus of this review is on translational studies utilizing large-animal models and clinical studies that provide fundamental insight into cellular and extracellular pathways contributing to post–myocardial infarction (MI) left ventricle (LV) remodeling. Specifically, both large-animal and clinical studies have examined the potential role of endogenous and exogenous stem cells to alter the course of LV remodeling. Interestingly, there have been alterations in LV remodeling with stem cell treatment despite a lack of long-term cell engraftment. The translation of the full potential of stem cell treatments to clinical studies has yet to be realized. The modulation of proteolytic pathways that contribute to the post-MI remodeling process has also been examined. On the basis of recent large-animal studies, there appears to be a relationship between stem cell treatment post-MI and the modification of proteolytic pathways, generating the hypothesis that stem cells leave an echo effect that moderates LV remodeling.
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影响因子：
15.9
作者：
GALIS, ZS;SUKHOVA, GK;LIBBY, P
通讯作者：
LIBBY, P
影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
DOI：
10.1016/s0735-1097(01)01200-1
发表时间：
2001-05-01
影响因子：
24
作者：
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DOI：
10.1152/ajpheart.2001.281.3.h987
发表时间：
2001-09-01
影响因子：
4.8
作者：
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通讯作者：
Spinale, FG
影响因子：
39.3
作者：
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通讯作者：
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