Dietary and commensal derived nutrients: shaping mucosal and systemic immunity.
Dietary and commensal derived nutrients: shaping mucosal and systemic immunity.
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DOI：
10.1016/j.coi.2012.07.006
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发表时间：
2012-08
影响因子：
7
通讯作者：
Belkaid Y
中科院分区：
文献类型：
--
作者：
Spencer SP;Belkaid Y
肠道是体内营养吸收的主要场所，同时也是共生微生物群的最高负担，也是病原体暴露的主要门户。因此，肠道的免疫网络依赖于饮食和共生信号来指导适当的功能。最近的进展强调了膳食来源的营养素和共生代谢物在塑造胃肠道免疫力中的作用。特别是，维生素 A 已被证明在肠道中具有显着的多效性作用。此外，饮食来源的 AHR 配体和共生代谢物现在正在成为粘膜免疫的重要参与者。因此，营养、共生微生物群和粘膜免疫系统都是密切相关的。
The intestine serves as the primary site of nutrient absorption in the body while also harboring the highest burden of commensal microflora and representing a major portal of pathogen exposure. As such, the immune network of the intestine relies on both dietary and commensal derived signals to guide appropriate function. Recent advances highlight the role of dietary derived nutrients and commensal derived metabolites in shaping gastrointestinal immunity. In particular, Vitamin A has been shown to have dominant and pleiotropic effects in the intestine. In addition, dietary derived AHR ligands and commensal derived metabolites are now emerging as important players in mucosal immunity. Thus nutrition, commensal microflora and the mucosal immune system are all intimately connected.
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影响因子：
32.4
作者：
Hall JA;Cannons JL;Grainger JR;Dos Santos LM;Hand TW;Naik S;Wohlfert EA;Chou DB;Oldenhove G;Robinson M;Grigg ME;Kastenmayer R;Schwartzberg PL;Belkaid Y
通讯作者：
Belkaid Y
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
影响因子：
32.4
作者：
Hall JA;Grainger JR;Spencer SP;Belkaid Y
通讯作者：
Belkaid Y
影响因子：
30.5
作者：
Denning, Timothy L.;Wang, Yi-Chong;Pulendran, Bali
通讯作者：
Pulendran, Bali
影响因子：
64.8
作者：
Josefowicz, Steven Z.;Niec, Rachel E.;Kim, Hye Young;Treuting, Piper;Chinen, Takatoshi;Zheng, Ye;Umetsu, Dale T.;Rudensky, Alexander Y.
通讯作者：
Rudensky, Alexander Y.