A model actin comet tail disassembling by severing.

A model actin comet tail disassembling by severing.
复制标题

DOI:
10.1088/1478-3975/8/4/046003
复制
发表时间:
2011-08
期刊:
影响因子:
2
通讯作者:
Carlsson AE
Carlsson AE
中科院分区:
生物学4区
文献类型:
--
作者:
Michalski PJ;Carlsson AE

文献摘要

参考文献

被引文献

相似文献

我们使用数值模拟来模拟肌动蛋白彗尾从小物体(珠子)表面生长并通过切断而分解的过程。我们探索了局部尾部半径和尾部长度等宏观特性对几个可控特性的依赖性,即珠子直径、珠子速度、单位长度的切断率和肌动蛋白凝胶网格尺寸。该模型预测 F-肌动蛋白密度最初呈指数衰减,随后在尾部边缘突然衰减,并预测彗尾直径沿尾部长度保持恒定。模拟结果用于拟合将彗尾长度与控制参数相关的公式,并且提出该公式提供了一种从简单的宏观测量中提取有关肌动蛋白凝胶网格尺寸和切割动力学的定量信息的方法。
We use a numerical simulation to model an actin comet tail as it grows from the surface of a small object (a bead) and disassembles by severing. We explore the dependence of macroscopic properties such as the local tail radius and tail length on several controllable properties, namely, the bead diameter, the bead velocity, the severing rate per unit length, and the actin gel mesh size. The model predicts an F-actin density with an initial exponential decay followed by an abrupt decay at the edge of the tail, and predicts that the comet tail diameter is constant along the length of the tail. The simulation results are used to fit a formula relating the comet tail length to the control parameters, and it is proposed that this formula offers a means to extract quantitative information on the actin gel mesh size and severing kinetics from simple macroscopic measurements.
DOI: 10.1083/jcb.200603149
发表时间: 2006-10-23
影响因子: 7.8
作者:
Brieher, William M;Kueh, Hao Yuan;Ballif, Bryan A;Mitchison, Timothy J
通讯作者: Mitchison, Timothy J
DOI: 10.1007/s00249-003-0370-3
发表时间: 2004-07-01
影响因子: 2
作者:
Plastino, J;Lelidis, I;Sykes, C
通讯作者: Sykes, C
DOI: 10.1016/j.molcel.2006.08.006
发表时间: 2006-10-06
期刊: MOLECULAR CELL
影响因子: 16
作者:
Andrianantoandro, Ernesto;Pollard, Thomas D.
通讯作者: Pollard, Thomas D.
DOI: 10.1038/44183
发表时间: 1999-10-07
期刊: NATURE
影响因子: 64.8
作者:
Loisel, TP;Boujemaa, R;Carlier, MF
通讯作者: Carlier, MF
DOI: 10.1016/s0006-3495(00)76473-3
发表时间: 2000-11-01
影响因子: 3.4
作者:
Gerbal, F;Chaikin, P;Prost, J
通讯作者: Prost, J