In Vitro and In Vivo Experimental Studies of PM(2.5) on Disease Progression.
In Vitro and In Vivo Experimental Studies of PM(2.5) on Disease Progression.
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DOI：
10.3390/ijerph15071380
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发表时间：
2018-07-01
影响因子：
--
通讯作者：
Lin CS
中科院分区：
文献类型：
--
作者：
Cho CC;Hsieh WY;Tsai CH;Chen CY;Chang HF;Lin CS
空气污染是全世界，特别是发展中国家的一个非常严重的问题。颗粒物（PM）是一种空气污染物，包括不同颗粒大小和化学成分的非均匀混合物。细颗粒物（PM2.5）的来源多种多样，其成分也可能对人产生不同的影响。PM2.5在多种疾病中的发病机制仍有待阐明。关于PM2.5在几种疾病中的流行病学研究历史悠久。大量研究表明，PM2.5可诱发多种慢性疾病，如呼吸系统损害、心血管功能障碍、糖尿病等。然而，与疾病进展的潜在机制相关的流行病学证据需要通过体外和体内研究来精确证明。PM2.5导致不良反应和慢性疾病的机制包括增加氧化应激，炎症反应和遗传毒性。本综述的目的是提供一个简短的概述，在体外和体内实验研究的PM2.5在各种疾病的进展，从过去的十年。总结的研究结果可以为PM2.5引起的疾病的机制和进展提供明确的信息。
Air pollution is a very critical issue worldwide, particularly in developing countries. Particulate matter (PM) is a type of air pollution that comprises a heterogeneous mixture of different particle sizes and chemical compositions. There are various sources of fine PM (PM2.5), and the components may also have different effects on people. The pathogenesis of PM2.5 in several diseases remains to be clarified. There is a long history of epidemiological research on PM2.5 in several diseases. Numerous studies show that PM2.5 can induce a variety of chronic diseases, such as respiratory system damage, cardiovascular dysfunction, and diabetes mellitus. However, the epidemiological evidence associated with potential mechanisms in the progression of diseases need to be proved precisely through in vitro and in vivo investigations. Suggested mechanisms of PM2.5 that lead to adverse effects and chronic diseases include increasing oxidative stress, inflammatory responses, and genotoxicity. The aim of this review is to provide a brief overview of in vitro and in vivo experimental studies of PM2.5 in the progression of various diseases from the last decade. The summarized research results could provide clear information about the mechanisms and progression of PM2.5-induced disease.
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影响因子：
10
作者：
Atkinson RW;Kang S;Anderson HR;Mills IC;Walton HA
通讯作者：
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影响因子：
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影响因子：
3.5
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作者：
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通讯作者：
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