Induction and Suppression of Innate Antiviral Responses by Hepatitis A Virus.
Induction and Suppression of Innate Antiviral Responses by Hepatitis A Virus.
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甲型肝炎病毒诱导和抑制先天抗病毒反应
DOI：
10.3389/fmicb.2018.01865
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发表时间：
2018
影响因子：
5.2
通讯作者：
Ma ZR
中科院分区：
文献类型：
--
作者：
Cao X;Xue YJ;Du JL;Xu Q;Yang XC;Zeng Y;Wang BB;Wang HZ;Liu J;Cai KZ;Ma ZR
甲型肝炎病毒（HAV）属于小核糖核酸病毒科。它是由粪-口传播引起的急性病毒性肝炎的病原体。RNA病毒被病原体相关的模式识别受体（PRR）如Toll样受体3（TLR 3）、视黄酸诱导基因I（RIG-I）和黑素瘤分化相关基因5（MDA 5）感知。PRR激活导致1型干扰素（IFN-α/β）的产生，作为抵抗病毒的第一道防线。然而，HAV已经开发了各种策略来损害先天免疫系统并促进宿主细胞内的病毒繁殖。甲型肝炎病毒在宿主体内的长期协同进化促进了有效的免疫拮抗策略的发展，这些策略可以积极对抗宿主的抗病毒反应。由HAV编码的蛋白酶可以切割线粒体抗病毒信号传导蛋白（MAVS，也称为IPS-1、VISA或Cardif）、含TIR结构域的衔接子诱导IFN-β（TRIF，也称为TICAM-1）和核因子-κB（NF-κB）必需调节剂（NEMO），它们分别是RIG-I样受体（RLR）、TLR 3和NF-κB信号传导中的关键衔接子蛋白。本文综述了近年来甲型肝炎病毒与宿主相互作用的研究进展，特别是对甲型肝炎病毒如何破坏先天免疫系统的抗病毒作用的研究。
Hepatitis A virus (HAV) belongs to the family Picornaviridae. It is the pathogen of acute viral hepatitis caused by fecal-oral transmission. RNA viruses are sensed by pathogen-associated pattern recognition receptors (PRRs) such as Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation-associated gene 5 (MDA5). PRR activation leads to production of type 1 interferon (IFN-α/β), serving as the first line of defense against viruses. However, HAV has developed various strategies to compromise the innate immune system and promote viral propagation within the host cells. The long coevolution of HAV in hosts has prompted the development of effective immune antagonism strategies that actively fight against host antiviral responses. Proteases encoded by HAV can cleave the mitochondrial antiviral signaling protein (MAVS, also known as IPS-1, VISA, or Cardif), TIR domain- containing adaptor inducing IFN-β (TRIF, also known as TICAM-1) and nuclear factor-κB (NF-κB) essential modulator (NEMO), which are key adaptor proteins in RIG-I-like receptor (RLR), TLR3 and NF-κB signaling, respectively. In this mini-review, we summarize all the recent progress on the interaction between HAV and the host, especially focusing on how HAV abrogates the antiviral effects of the innate immune system.
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影响因子：
64.8
作者：
Feng Z;Hensley L;McKnight KL;Hu F;Madden V;Ping L;Jeong SH;Walker C;Lanford RE;Lemon SM
通讯作者：
Lemon SM
影响因子：
64.8
作者：
Jiang, Fuguo;Ramanathan, Anand;Miller, Matthew T.;Tang, Guo-Qing;Gale, Michael, Jr.;Patel, Smita S.;Marcotrigiano, Joseph
通讯作者：
Marcotrigiano, Joseph
影响因子：
5.8
作者：
Dixon LJ;Barnes M;Tang H;Pritchard MT;Nagy LE
通讯作者：
Nagy LE
影响因子：
13.3
作者：
Debing, Yannick;Neyts, Johan;Thibaut, Hendrik Jan
通讯作者：
Thibaut, Hendrik Jan
影响因子：
11.4
作者：
Kaplan, G;Totsuka, A;Feinstone, SM
通讯作者：
Feinstone, SM