Tuberculosis and illicit drug use: review and update.

Tuberculosis and illicit drug use: review and update.
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DOI:
10.1086/594126
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发表时间:
2009-01-01
期刊:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子:
--
通讯作者:
Garfein RS
Garfein RS
中科院分区:
其他
文献类型:
--
作者:
Deiss RG;Rodwell TC;Garfein RS

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非法药物使用者仍然是结核病感染和疾病的高风险群体。在这篇文章中,我们介绍了关于结核病与药物使用之间关系的最新综述,总结了十多年来的新研究。在一些国家,吸毒者,特别是注射吸毒者推动了结核病的流行。成功识别和治疗吸毒者中的结核病仍然是结核综合战略的一个重要组成部分,但吸毒者为结核诊断和控制带来了一系列独特的挑战。新的诊断方式,包括干扰素γ释放测定法(IGRAs),为改善这一群体的诊断和监测提供了潜力,同时也证实了将直接观察疗法(DOT)与药物滥用治疗相结合的治疗策略。特殊考虑,包括病毒性肝炎合并感染和利福平/美沙酮药物相互作用,值得临床注意,并在此更新。
Illicit drug users continue to be a group at high risk for tuberculosis (TB) infection and disease. In this article, we present an updated review on the relationship between TB and drug use, summarizing more than a decade of new research. Drug users, and injection drug users in particular, have driven TB epidemics in a number of countries. The successful identification and treatment of TB among drug users remains an important component of a comprehensive TB strategy, but drug users present a unique set of challenges for TB diagnosis and control. New diagnostic modalities, including interferon-γ release assays (IGRAs), offer potential for improved diagnosis and surveillance among this group, alongside proven treatment strategies which incorporate the use of directly-observed therapy (DOT) with treatment for drug abuse. Special considerations, including co-infection with viral hepatitis and the Rifampin/methadone drug interaction, warrant clinical attention and are also updated here.
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