Sequential administrations of polyriboinosinic acid and polyribocytidylic acid induce interferon and depress the hepatic cytochrome P-450-dependent monooxygenase system.
Sequential administrations of polyriboinosinic acid and polyribocytidylic acid induce interferon and depress the hepatic cytochrome P-450-dependent monooxygenase system.
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连续施用聚核糖肌苷酸和聚核糖胞苷酸可诱导干扰素并抑制肝细胞色素 P-450 依赖性单加氧酶系统。
DOI:
10.1016/0006-291x(82)91802-2
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发表时间:
1982
影响因子:
3.1
通讯作者:
Mannering,GJ
中科院分区:
文献类型:
--
作者:
Deloria,LB;Mannering,GJ
Double-stranded polyriboinosinic acid·polyribocytidylic acid is a potent interferon inducing agent and depressant of hepatic cytochrome P-450 monooxygenase systems. Single-stranded polyriboinosinic acid or polyribocytidylic acid are not. However, it is known that interferon is induced in mice when the administration of polyriboinosinic acid is followed shortly thereafter by the administration of polyribocytidylic acid. The current study demonstrates that this sequential administration of single-stranded polynucleotides induces serum and hepatic interferon and depresses the cytochrome P-450 systems. Neither of these effects were seen when the order of administration of these polynucleotides was reversed.
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影响因子:
9
作者:
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通讯作者:
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DOI:
--
发表时间:
1982
期刊:
Surgery, gynecology & obstetrics
影响因子:
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通讯作者:
W. Longmire
DOI:
--
发表时间:
1980
期刊:
Surgery, gynecology & obstetrics
影响因子:
--
作者:
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通讯作者:
Aldrete,JA