Sequential administrations of polyriboinosinic acid and polyribocytidylic acid induce interferon and depress the hepatic cytochrome P-450-dependent monooxygenase system.

Sequential administrations of polyriboinosinic acid and polyribocytidylic acid induce interferon and depress the hepatic cytochrome P-450-dependent monooxygenase system.
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连续施用聚核糖肌苷酸和聚核糖胞苷酸可诱导干扰素并抑制肝细胞色素 P-450 依赖性单加氧酶系统。

DOI:
10.1016/0006-291x(82)91802-2
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发表时间:
1982
影响因子:
3.1
通讯作者:
Mannering,GJ
Mannering,GJ
中科院分区:
生物学4区
文献类型:
--
作者:
Deloria,LB;Mannering,GJ

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双链多聚肌苷酸·多聚核糖胞苷酸是一种有效的干扰素诱导剂,也是肝细胞色素P-450单加氧酶系统的抑制剂。单链多聚核糖肌苷酸或多聚核糖胞苷酸则不是。然而,已知当施用聚核糖肌苷酸之后不久施用聚核糖胞苷酸时,在小鼠中诱导干扰素。目前的研究表明,这种顺序管理的单链多核苷酸诱导血清和肝脏干扰素和抑制细胞色素P-450系统。当这些多核苷酸的给药顺序颠倒时,没有观察到这些效应。
Double-stranded polyriboinosinic acid·polyribocytidylic acid is a potent interferon inducing agent and depressant of hepatic cytochrome P-450 monooxygenase systems. Single-stranded polyriboinosinic acid or polyribocytidylic acid are not. However, it is known that interferon is induced in mice when the administration of polyriboinosinic acid is followed shortly thereafter by the administration of polyribocytidylic acid. The current study demonstrates that this sequential administration of single-stranded polynucleotides induces serum and hepatic interferon and depresses the cytochrome P-450 systems. Neither of these effects were seen when the order of administration of these polynucleotides was reversed.
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