Elevated blood pressure and analgesic overuse in chronic daily headache: an outpatient clinic-based study from China.
Elevated blood pressure and analgesic overuse in chronic daily headache: an outpatient clinic-based study from China.
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慢性每日头痛导致血压升高和镇痛过度：一项来自中国的门诊研究
DOI：
10.1186/1129-2377-14-51
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发表时间：
2013-06-17
期刊：
影响因子：
--
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Huang Q;Li W;Li N;Wang J;Tan G;Chen L;Qin G;Liang X;Zhou J
许多研究报道，高血压常见于慢性日常性头痛（CDH）及其亚型慢性偏头痛（CM），但其原因尚不清楚。我们的临床文献回顾表明，镇痛药过度使用可能与血压升高有关，因此我们进行了本研究，以调查CDH及其亚型中血压升高的频率及其与镇痛药过度使用的关系。方法对根据国际头痛学会标准诊断为CDH的神经内科门诊患者进行横断面研究。将CDH患者分为CM组和非CM组，并对有无过度使用镇痛药进行亚分类。结果27.96%的CDH患者血压升高。与非CM患者相比，CM患者头痛持续时间更长，疼痛强度更大，有头痛家族史和止痛药过度使用史的患者也更常见，但两组血压频率升高无差异。近三分之一的患者存在镇痛药过度使用；其中96.8%含有对乙酰氨基酚。镇痛药过度使用组和非镇痛药过度使用组的头痛发生率均高于非镇痛药过度使用组。结论CM组患者头痛持续时间较长，强度较重，但血压升高频率不高于非CM组。镇痛药的过度使用可能是CDH及其亚型患者血压升高频率较高的原因。这可能对临床医生改善CDH管理具有预测价值。
BackgroundMany studies have reported that hypertension is common in chronic daily headache (CDH) and its subtype chronic migraine (CM), but the reason is still poorly understood. Our clinical literature review suggested that analgesic overuse may be associated with elevated blood pressure (BP), so we performed the present study to investigate the frequency of elevated BP and its link with analgesic overuse in CDH and its subtypes.MethodsA cross-sectional study was conducted in neurology outpatients with a diagnosis of CDH according to International Headache Society criteria. CDH patients were classified into CM and non-CM groups, and subclassified with or without analgesic overuse.ResultsElevated BP was present in 27.96% of CDH patients. Compared with non-CM patients, patients with CM had a longer duration of headache and more severe pain intensity, and a family history of headache and analgesic overuse were also more common, but the elevated BP frequency was not different between the two groups. Almost one-third of the patients had analgesic overuse; 96.8% of which comprised acetaminophen-containing agents. Those with analgesic overuse had a higher frequency of headache than those without analgesic overuse in both the CM and non-CM groups.ConclusionsAlthough the CM patients had a longer duration of headache, more severe intensity, the frequency of elevated BP wasn’t higher than non-CM group. Analgesic overuses maybe the reason of higher frequency of elevated BP in CDH and its subtypes. This may have predictive value for clinicians to improve CDH management.
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