House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters.
House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters.
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DOI：
10.1289/ehp.0901332
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发表时间：
2010-03
影响因子：
10.4
通讯作者：
Stapleton HM
中科院分区：
文献类型：
--
作者：
Meeker JD;Stapleton HM
有机磷酸盐（OP）化合物，例如三（1，3-二氯-2-丙基）磷酸盐（TDCPP）和磷酸三苯酯（TPP），通常在多种材料中用作添加剂阻燃剂和增塑剂。尽管OP阻燃剂可能会广泛影响人类，但缺乏关于潜在健康影响的人类和动物数据。我们探讨了TDCPP和TPP浓度与激素水平和精液质量参数的关系。我们分析了从美国不孕症诊所招募的50名男性的TDCPP和TPP。生殖和甲状腺激素水平的关系，以及精液质量参数，进行了评估，使用粗和多变量线性回归。TDCPP和TPP分别在96%和98%的样品中检测到，浓度变化很大，最高可达1.8 mg/g。在校正了年龄和体重指数的模型中，TDCPP的四分位距（IQR）增加与游离甲状腺素下降3%（95%置信区间（CI），-5%至1%）和催乳素增加17%（95% CI，4-32%）相关。TDCPP和游离雄激素指数之间存在提示性负相关，在调整后的模型中变得不那么明显。在调整后的模型中，TPP的IQR增加与催乳素增加10%（95% CI，2-19%）和精子浓度降低19%（95% CI，−30%至−5%）相关。OP阻燃剂可能与男性激素水平改变和精液质量下降有关。需要对人类暴露于OP阻燃剂的来源和水平以及相关的健康结果进行更多的研究。
Organophosphate (OP) compounds, such as tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), are commonly used as additive flame retardants and plasticizers in a wide range of materials. Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects. We explored relationships of TDCPP and TPP concentrations in house dust with hormone levels and semen quality parameters. We analyzed house dust from 50 men recruited through a U.S. infertility clinic for TDCPP and TPP. Relationships with reproductive and thyroid hormone levels, as well as semen quality parameters, were assessed using crude and multivariable linear regression. TDCPP and TPP were detected in 96% and 98% of samples, respectively, with widely varying concentrations up to 1.8 mg/g. In models adjusted for age and body mass index, an interquartile range (IQR) increase in TDCPP was associated with a 3% [95% confidence interval (CI), −5% to −1%) decline in free thyroxine and a 17% (95% CI, 4–32%) increase in prolactin. There was a suggestive inverse association between TDCPP and free androgen index that became less evident in adjusted models. In the adjusted models, an IQR increase in TPP was associated with a 10% (95% CI, 2–19%) increase in prolactin and a 19% (95% CI, −30% to −5%) decrease in sperm concentration. OP flame retardants may be associated with altered hormone levels and decreased semen quality in men. More research on sources and levels of human exposure to OP flame retardants and associated health outcomes are needed.
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影响因子：
10.4
作者：
Colt, JS;Zahm, SH;Hartge, P
通讯作者：
Hartge, P
影响因子：
2.8
作者：
G端ven, M;Bayram, F;Kelestimur, F
通讯作者：
Kelestimur, F
影响因子：
4.1
作者：
Fang, H;Tong, WD;Sheehan, DM
通讯作者：
Sheehan, DM
DOI：
10.1158/1055-9965.epi-08-0960
发表时间：
2009-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Enewold L;Zhu K;Ron E;Marrogi AJ;Stojadinovic A;Peoples GE;Devesa SS
通讯作者：
Devesa SS
影响因子：
8.8
作者：
Marklund, A;Andersson, B;Haglund, P
通讯作者：
Haglund, P