Methamphetamine-enhanced female sexual motivation is dependent on dopamine and progesterone signaling in the medial amygdala.
Methamphetamine-enhanced female sexual motivation is dependent on dopamine and progesterone signaling in the medial amygdala.
复制标题
DOI：
10.1016/j.yhbeh.2014.10.004
复制
发表时间：
2015-01
影响因子：
3.5
通讯作者：
Mong, Jessica A.
中科院分区：
文献类型：
--
作者：
Holder, Mary K.;Veichweg, Shaun S.;Mong, Jessica A.
关键词：
Methamphetamine (METH) is a psychomotor stimulant strongly associated with increases in sexual drive and impulsive sexual behaviors that often lead to unsafe sexual practices. In women METH users, such practices have been associated with increases in unplanned pregnancies and sexually transmitted diseases. Despite this significant heath concern, the neural mechanisms underlying this drug-sex association are not known. We previously established a rodent model of METH-facilitated female sexual behavior in which estradiol and progesterone interact with METH to increase motivational components of female behavior and neuronal activation in the posterodorsal medial amygdala (MePD). The current study more directly examines the mechanisms underlying the drug-sex interaction. Here, we hypothesize that METH-induced increases in MePD dopamine signaling bridge the METH-hormone interaction. In support of this hypothesis, we found that excitotoxic lesions targeted to the MePD attenuated the METH-induced increases in proceptive behavior. Furthermore, infusion of a D1 agonist into the MePD increased proceptive behavior, while infusion of a D1 antagonist blocked the ability of METH to increase proceptive behaviors. Additionally, we found that METH-treatment increased progesterone receptor (PR)- immunoreactivity in the MePD, suggesting an interaction between dopamine and progesterone signaling. Indeed, infusions of the PR antagonist, RU486, prevented METH-induced increases in sexual behavior. Thus, taken together, the current findings suggest dopamine in the MePD modulates enhanced sexual motivation via an amplification of progesterone signaling and contributes to a better understanding of the neurobiology of drug-enhanced sexual behaviors.
登录
查看更多内容
影响因子：
5.3
作者：
Chu, HP;Etgen, AM
通讯作者：
Etgen, AM
DOI：
10.3181/00379727-51-13979
发表时间：
1942-12-01
影响因子：
--
作者：
Beach, FA
通讯作者：
Beach, FA
影响因子：
3.8
作者：
ERSKINE, MS
通讯作者：
ERSKINE, MS
影响因子：
3.5
作者：
Afonso, VM;Pfaus, JG
通讯作者：
Pfaus, JG
DOI：
10.1002/neu.480210502
发表时间：
1990-07-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
BLAUSTEIN, JD;TURCOTTE, JC
通讯作者：
TURCOTTE, JC