The Association of Chemotherapy-Induced Peripheral Neuropathy Symptoms and the Risk of Falling.
The Association of Chemotherapy-Induced Peripheral Neuropathy Symptoms and the Risk of Falling.
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DOI：
10.1001/jamaneurol.2016.0383
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发表时间：
2016-07-01
期刊：
影响因子：
29
通讯作者：
Mooney K
中科院分区：
文献类型：
--
作者：
Kolb NA;Smith AG;Singleton JR;Beck SL;Stoddard GJ;Brown S;Mooney K
Chemotherapy induced peripheral neuropathy is a common side effect of neurotoxic chemotherapy resulting in pain, sensory loss and decreased quality of life. Few studies have prospectively examined the relationship between sensory neuropathy symptoms, falls and fall related injuries in those receiving neurotoxic chemotherapy. Determine the association between the symptoms of chemotherapy induced peripheral neuropathy (CIPN) and fall risk in those receiving neurotoxic chemotherapy. Patients starting neurotoxic chemotherapy with a taxane or platinum called a novel automated phone system daily for one full course of chemotherapy. The phone system, “Symptom Care @ Home” utilized a series of relevant CIPN questions to track symptoms on a 0–10 ordinal scale and contained a questionnaire about falls. Those reporting a numbness and tingling severity of 3 or greater for at least 10 days were considered to have significant CIPN symptoms and were compared to those who did not. Ambulatory participants at an academic cancer center. A consecutive sample of breast, ovarian and lung cancer patients beginning neurotoxic chemotherapy was recruited from oncology clinics. The study population was largely female (94%) and Caucasian (96%). Chemotherapy with a neurotoxic taxane or platinum agent. Patient reported fall events (falls or near falls) and fall related injuries. The hypothesis was generated after data collection but prior to data analysis. 32/116 patients met the predetermined criteria for CIPN symptoms. The mean duration of follow up was 62 days with 51 calls completed per participant. 74 fall events were reported. Those with CIPN symptoms were nearly 3 times more likely to have a fall event than those without (HR 2.67, CI 1.62–4.41, p<0.001). The CIPN group was more likely to obtain medical care for falls (25.0% vs. 7.1%, p=0.013). These findings suggest the sensory symptoms of CIPN are an indicator of increased fall risk and health care utilization. This study demonstrates the utility of a novel phone based system to track neuropathy symptoms. Careful monitoring and coaching of patients receiving neurotoxic chemotherapy for new sensory symptoms may facilitate more effective fall prevention strategies.
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影响因子：
--
作者：
Rosen, Tony;Mack, Karin A;Noonan, Rita K
通讯作者：
Noonan, Rita K
影响因子：
3.5
作者：
CAVANAGH, PR;DERR, JA;ORCHARD, TJ
通讯作者：
ORCHARD, TJ
影响因子：
3.1
作者：
Gewandter, J. S.;Fan, L.;Mohile, S. G.
通讯作者：
Mohile, S. G.
影响因子：
50.5
作者：
Hertz, D. L.;Roy, S.;Dees, E. C.
通讯作者：
Dees, E. C.
DOI：
10.1093/gerona/50a.4.m211
发表时间：
1995-07-01
影响因子：
5.1
作者：
RICHARDSON, JK;HURVITZ, EA
通讯作者：
HURVITZ, EA