H2O2-responsive molecularly engineered polymer nanoparticles as ischemia/reperfusion-targeted nanotherapeutic agents.
H2O2-responsive molecularly engineered polymer nanoparticles as ischemia/reperfusion-targeted nanotherapeutic agents.
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DOI：
10.1038/srep02233
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发表时间：
2013
影响因子：
4.6
通讯作者：
Kang, Peter M.
中科院分区：
文献类型：
--
作者：
Lee, Dongwon;Bae, Soochan;Hong, Donghyun;Lim, Hyungsuk;Yoon, Joo Heung;Hwang, On;Park, Seunggyu;Ke, Qingen;Khang, Gilson;Kang, Peter M.
活性氧(ROS)的过量产生是缺血再灌注(I/R)损伤发生的主要原因。过氧化氢(H_2O_2)是I/R过程中产生的最丰富的ROS形式，可引起炎症、细胞凋亡和随后的组织损伤。在这里，我们报告了由含有香草醇(VA)的共聚草酸(PVAX)制成的过氧化氢响应型抗氧化剂纳米颗粒，作为一种新型的I/R靶向纳米治疗剂。PVAX的设计目的是在其主干上共价结合VA和H_2O_2响应型过氧草酸酯键。因此，PVAX纳米粒子能够降解和释放VA，从而减少ROS的产生，并发挥抗炎和抗细胞凋亡的活性。在小鼠的后肢I/R和肝脏I/R模型中，PVAX纳米颗粒与过量产生的过氧化氢发生特异性反应，并发挥高效的抗炎和抗凋亡活性，从而减少细胞损伤。因此，PVAX纳米粒子作为I/R损伤和过氧化氢相关疾病的纳米治疗剂具有巨大的潜力。
The main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury is the overproduction of reactive oxygen species (ROS). Hydrogen peroxide (H2O2), the most abundant form of ROS produced during I/R, causes inflammation, apoptosis and subsequent tissue damages. Here, we report H2O2-responsive antioxidant nanoparticles formulated from copolyoxalate containing vanillyl alcohol (VA) (PVAX) as a novel I/R-targeted nanotherapeutic agent. PVAX was designed to incorporate VA and H2O2-responsive peroxalate ester linkages covalently in its backbone. PVAX nanoparticles therefore degrade and release VA, which is able to reduce the generation of ROS, and exert anti-inflammatory and anti-apoptotic activity. In hind-limb I/R and liver I/R models in mice, PVAX nanoparticles specifically reacted with overproduced H2O2 and exerted highly potent anti-inflammatory and anti-apoptotic activities that reduced cellular damages. Therefore, PVAX nanoparticles have tremendous potential as nanotherapeutic agents for I/R injury and H2O2-associated diseases.
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影响因子：
15.9
作者：
GOTTLIEB, RA;BURLESON, KO;ENGLER, RL
通讯作者：
ENGLER, RL
DOI：
10.1016/s0967-2109(02)00070-4
发表时间：
2002-12-01
期刊：
CARDIOVASCULAR SURGERY
影响因子：
--
作者：
Blaisdell, FW
通讯作者：
Blaisdell, FW
影响因子：
6.7
作者：
Lee, Ji Yun;Jang, Young Woon;Kim, Chang Jong
通讯作者：
Kim, Chang Jong
影响因子：
15
作者：
Chang, MCY;Pralle, A;Chang, CJ
通讯作者：
Chang, CJ
影响因子：
7.4
作者：
Sawyer, RT;Dobis, DR;Day, BJ
通讯作者：
Day, BJ