A systematic review of placental pathology in maternal diabetes mellitus.
A systematic review of placental pathology in maternal diabetes mellitus.
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DOI：
10.1016/j.placenta.2014.11.021
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发表时间：
2015-02
期刊：
影响因子：
3.8
通讯作者：
Bentley-Lewis, R.
中科院分区：
文献类型：
--
作者：
Huynh, J.;Dawson, D.;Roberts, D.;Bentley-Lewis, R.
在妊娠合并糖尿病期间，人类胎盘会经历一系列的功能和结构病理变化，例如胎盘重量增加，胎盘病变的发生率增加，包括绒毛成熟缺陷和纤维素样坏死。不同研究报告的病理结果有所不同，可能反映了研究参与者在糖尿病类型、研究方法或血糖控制方面的差异。或者，这些差异可能代表了不同代谢性疾病的不同生物适应。为了澄清这些区别，我们对Pubmed和Embase上的英文引文进行了全面的回顾，关键词分别为“糖尿病”、“胎盘”和“病理”。对相关的摘要进行综述，然后对全文文章进行综述，以全面总结目前与妊娠期和妊娠期糖尿病相关的病理发现，以及了解血糖控制对胎盘病理的影响。与母亲糖尿病最相关的胎盘异常是绒毛未成熟发生率增加，血管生成指标增加，以及胎盘重量增加。文献表明，尽管胎盘异常相似，但胎盘病理的差异可能反映了不同类型糖尿病之间的病理生理学差异。因此，标准化用于定义胎盘病变的术语是必要的。此外，还需要进一步研究病理生理学、血糖控制和临床因素，如婴儿性别、体重和种族对胎盘结构和功能的影响。
During a pregnancy complicated by diabetes, the human placenta undergoes a number of functional and structural pathologic changes, such as increased placental weight and increased incidence of placental lesions including villous maturational defects and fibrinoid necrosis. The pathologic findings reported have differed among studies, potentially reflecting differences in type of diabetes, study methodology, or glycemic control of study participants. Alternatively, these discrepancies may represent different biologic adaptations to distinct metabolic diseases. In order to clarify these distinctions, we conducted a comprehensive review of English language citations in Pubmed and Embase using the keywords “diabetes”, “placenta”, AND “pathology”. Abstracts were reviewed for relevance then full-text articles were reviewed in order to extract a comprehensive summary of current pathological findings associated with pregestational and gestational diabetes mellitus, as well as an understanding of the impact of glycemic control on placental pathology. Placental abnormalities most consistently associated with maternal diabetes are an increased incidence of villous immaturity, increased measures of angiogenesis, and increased placental weight. The literature suggests that, despite similarities in placental abnormalities, differences in placental pathology may reflect differences in pathophysiology among different types of diabetes. Consequently, standardization of terminology used to define placental lesions is warranted. Moreover, further research is needed to investigate the impact of pathophysiology, glycemic control and clinical factors, such as infant sex, weight and race, on placental structure and function.
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DOI：
10.1111/j.1471-0528.1986.tb07809.x
发表时间：
1986-01-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
BOYD, PA;SCOTT, A;KEELING, JW
通讯作者：
KEELING, JW
影响因子：
16.2
作者：
Desoye, Gernot;Mouzon, Sylvie Hauguel-De
通讯作者：
Mouzon, Sylvie Hauguel-De
影响因子：
3.5
作者：
Bentley-Lewis, Rhonda;Dawson, Deanna L.;Roberts, Drucilla J.
通讯作者：
Roberts, Drucilla J.
DOI：
10.1007/bf02581119
发表时间：
1976-01-01
期刊：
ACTA DIABETOLOGICA LATINA
影响因子：
--
作者：
JACOMO, KH;BENEDETTI, WL;ALVAREZ, H
通讯作者：
ALVAREZ, H
影响因子：
4.3
作者：
Daskalakis, George;Marinopoulos, Spyros;Antsaklis, Aris
通讯作者：
Antsaklis, Aris