Long Distance From Microvessel to Cancer Cell Predicts Poor Prognosis in Non-Small Cell Lung Cancer Patients.
Long Distance From Microvessel to Cancer Cell Predicts Poor Prognosis in Non-Small Cell Lung Cancer Patients.
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微血管到癌细胞的远距离预示着非小细胞肺癌患者的不良预后
DOI：
10.3389/fonc.2021.632352
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发表时间：
2021
影响因子：
4.7
通讯作者：
Fang L
中科院分区：
文献类型：
--
作者：
Ding H;Sun J;Song Y;Xin W;Zhu J;Zhong L;Chen Y;Zhang Y;Tong Y;Fang L
背景：微血管密度以及血管与癌细胞之间的扩散距离决定了微血管的供应是营养和药物输送的关键。因此，我们评估了微血管到癌细胞的距离(Dmvcc)及其在非小细胞肺癌(NSCLC)患者预后中的作用。方法对原发性非小细胞肺癌患者的临床资料进行回顾性分析。肿瘤标本用CD31免疫组织化学染色显示微血管。Dmvcc被定义为从每个微血管到其在单个患者“热点”中最近的癌细胞的平均距离。采用5种策略将患者分为近距离组和长距离组，包括按中值二分法、最佳截断法、三分法、四分割法和每10微米递增法。采用不同的Dmvcc策略进行单变量和多变量分析，评估Dmvcc与生存率之间的相关性。结果共分析100例患者。Dmvcc的中位数为13.1μm，范围为1.6~269.7μm，平均值为24.4±33.5μm。Dmvcc与总生存期(OS)显著相关(p=0.001-0.000004)，无进展生存期(PFS)按最佳临界值(p=0.024)、三分割法(p=0.041)和每10µm增加(p=0.040)分类。Dmvcc与总生存期(OS)显著相关(p=0.001-0.000004)。在调整其他因素后，Dmvcc与无进展生存期(PFS)呈正相关。Dmvcc预测预后的最佳临界值为20μm。Dmvcc(≥20μm)较长的患者预后较差(OS：HR=13.5，95CI：4.42~41.18，p=0.000005；PFS：3.26，95CI：1.56~6.81，p=0.002)。每10微米高的Dmvcc与癌症相关的死亡和进展风险分别显著增加98%(p=0.0001)和30%(p=0.044)。结论非小细胞肺癌组织从微血管到癌细胞的距离不同，距离长与生存率差密切相关。
Background Blood supply, which is crucial for nutrition and drug delivery, was determined by microvessel density as well as the diffusion distance between vessels and cancer cells. Therefore, we evaluated the distance from microvessels to cancer cells (Dmvcc) and its role in the prognosis of non-small cell lung cancer (NSCLC) patients. Methods Patients with primary NSCLC were retrospectively analyzed. The tumor samples were immunochemically stained with CD31 to visualize the microvessels. The Dmvcc was defined as the mean distance from each microvessel to its nearest cancer cell in the “hot-spot” of an individual patient. The patients were stratified into short- and long-distance groups using five strategies, including dichotomy by the median value, optimal cutoff, trichotomy, quartation and per-10 µm increase. The correlation between the Dmvcc and survival was evaluated by using univariate and multivariate analyses with various Dmvcc strategies. Results In total, 100 patients were analyzed. The median value of Dmvcc was 13.1 μm (ranged, 1.6 to 269.7 μm; mean value, 24.4 ± 33.5 μm). The optimal cutoff value of Dmvcc for predicting survival outcome was 20 μm. Dmvcc was significantly related to overall survival (OS) with all the five categories (p = 0.001–0.000004) and progression-free survival (PFS) categorized by optimal cutoff value (p = 0.024), trichotomy (p = 0.041) and per-10 µm increase (p = 0.040) after adjusting for other factors. Patients with longer Dmvcc (≥20 μm) were observed to have poor survival outcomes (OS: HR = 13.5, 95CI: 4.42–41.18, p = 0.000005; PFS: 3.26, 95CI: 1.56–6.81, p = 0.002). A high Dmvcc per-10 µm was associated with a significantly increased risk of cancer-related death and progression by 98% (p = 0.0001) and 30% (p = 0.044), respectively. Conclusion The NSCLC tissues had varying distances from microvessels to cancer cells, and long distances were strongly associated with poor survival.
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DOI：
10.1016/j.neo.2020.10.001
发表时间：
2020-12
期刊：
Neoplasia (New York, N.Y.)
影响因子：
--
作者：
Krishnamachary B;Mironchik Y;Jacob D;Goggins E;Kakkad S;Ofori F;Dore-Savard L;Bharti SK;Wildes F;Penet MF;Black ME;Bhujwalla ZM
通讯作者：
Bhujwalla ZM
影响因子：
16.1
作者：
Li, Yinghuan;Wang, Jie;Wientjes, M. Guillaume;Au, Jessie L. -S.
通讯作者：
Au, Jessie L. -S.
DOI：
10.1038/sj.neo.7900037
发表时间：
1999-08-01
期刊：
Neoplasia (New York)
影响因子：
--
作者：
Gillies, Robert J.;Schornack, Paul A.;Raghunand, Natarajan
通讯作者：
Raghunand, Natarajan
影响因子：
10.3
作者：
Bais, Carlos;Mueller, Barbara;Birrer, Michael J.
通讯作者：
Birrer, Michael J.
影响因子：
3.5
作者：
Dewhirst, MW
通讯作者：
Dewhirst, MW