Biomechanical aspects of the muscle-bone interaction.
Biomechanical aspects of the muscle-bone interaction.
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DOI：
10.1007/s11914-014-0244-x
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发表时间：
2015-02
影响因子：
4.3
通讯作者：
Warden, Stuart J.
中科院分区：
文献类型：
--
作者：
Avin, Keith G.;Bloomfield, Susan A.;Gross, Ted S.;Warden, Stuart J.
关键词：
人们对骨骼肌和骨骼之间的相互作用越来越感兴趣，特别是在遗传和分子水平上。然而，肌肉和骨骼之间的遗传和分子联系只有在组织的基本机械耦合的背景下才能实现。这种生物力学和生理学的联系很明显，因为肌肉附着在骨骼上，并通过功能活动诱导暴露于各种机械刺激。骨细胞对机械刺激或机械刺激缺失的反应性已经得到了很好的证实。然而，关于肌肉力量如何作用于骨骼以调节骨骼稳态和适应的问题仍然存在。同样，肌肉对骨骼产生的各种但独特的刺激（如低强度、高频刺激）的贡献仍有待确定。本文主要讨论肌肉和骨骼之间的力学关系。在此过程中，我们探索了肌肉对骨骼的刺激，能够调查这种关系的模型，以及这些模型产生的最新数据。
There is growing interest in the interaction between skeletal muscle and bone, particularly at the genetic and molecular levels. However, the genetic and molecular linkages between muscle and bone are achieved only within the context of the essential mechanical coupling of the tissues. This biomechanical and physiological linkage is readily evident as muscles attach to bone and induce exposure to varied mechanical stimuli via functional activity. The responsiveness of bone cells to mechanical stimuli, or their absence, is well established. However, questions remain regarding how muscle forces applied to bone serve to modulate bone homeostasis and adaptation. Similarly, the contributions of varied, but unique, stimuli generated by muscle to bone (such as low-magnitude, high-frequency stimuli) remains to be established. The current article focuses upon the mechanical relationship between muscle and bone. In doing so, we explore the stimuli that muscle imparts upon bone, models that enable investigation of this relationship, and recent data generated by these models.
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影响因子：
5.8
作者：
Gallagher, JC;Rapuri, PB;Detter, JR
通讯作者：
Detter, JR
影响因子：
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作者：
Armstrong, DW;Rue, JPH;Frassica, FJ
通讯作者：
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DOI：
10.1002/jbmr.1969
发表时间：
2013-07
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
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作者：
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通讯作者：
Esser KA
影响因子：
3.8
作者：
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通讯作者：
Burr, DB
影响因子：
4.1
作者：
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通讯作者：
Gross, Ted S.