Modulation of Glycine Sites Enhances Social Memory in Rats using PQQ Combined with D-serine
Modulation of Glycine Sites Enhances Social Memory in Rats using PQQ Combined with D-serine
复制标题
使用 PQQ 与 D-丝氨酸组合调节甘氨酸位点可增强大鼠的社交记忆
DOI：
10.1016/j.bbr.2016.04.034
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发表时间：
2016-07
影响因子：
2.7
通讯作者：
Shishi Mao
中科院分区：
文献类型：
--
作者：
Xingqin Zhou;Dong Liu;Rongjun Zhang;Ying Peng;Xiaofeng Qin;Shishi Mao
The aim of study was to investigate the effects of pyrroloquinoline quinone (PQQ) combined withd-serine on the modulation of glycine sites in the brain of rats using social recognition test. Rats were divided into seven groups (n = 10) and given repeated intraperitoneal (ip) injections of saline, MK-801 (0.5 mg/kg), clozapine (1 mg/kg), haloperidol (0.1 mg/kg),d-serine (0.8 g/kg), PQQ (2.0 μg/kg), ord-serine (0.4 g/kg) combined with PQQ (1.0 μg/kg) for seven days. A social recognition test, including assessment of time-dependent memory impairment, was performed. A non-competitive NMDA receptor antagonist, MK-801, significantly impaired social memory, and this impairment was significantly repaired with an atypical antipsychotic (clozapine) but not with a typical antipsychotic (haloperidol). Likewise,d-serine combined with PQQ significantly improved MK-801-disrupted cognition in naïve rats, whereas haloperidol was ineffective. The present results show that the co-agonist NMDA receptor treated with PQQ andd-serine enhances social memory and may be an effective approach for treating the cognitive dysfunction observed in schizophrenic patients. PQQ stimulates glycine modulatory sites by which it may antagonize indirectly by removing glycine from the synaptic cleft or by binding the unsaturated site withd-serine in the brain, providing the insights into future research of central nervous system and drug discovery.
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影响因子：
21.1
作者：
W. Danysz;C. Parsons
通讯作者：
W. Danysz;C. Parsons
影响因子：
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作者：
T. Shimazaki;Ayaka Kaku;S. Chaki
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影响因子：
7.6
作者：
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通讯作者：
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影响因子：
56.9
作者：
KILLGORE, J;SMIDT, C;RUCKER, RB
通讯作者：
RUCKER, RB
影响因子：
2.7
作者：
Karasawa, Jun-Ichi;Hashimoto, Kenji;Chaki, Shigeyuki
通讯作者：
Chaki, Shigeyuki