Genome-wide ancestry and introgression in a Zambian baboon hybrid zone.
Genome-wide ancestry and introgression in a Zambian baboon hybrid zone.
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DOI：
10.1111/mec.15858
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发表时间：
2021-04
影响因子：
4.9
通讯作者：
Phillips-Conroy JE
中科院分区：
文献类型：
--
作者：
Chiou KL;Bergey CM;Burrell AS;Disotell TR;Rogers J;Jolly CJ;Phillips-Conroy JE
自然界中的杂交提供了对早期物种及其杂交种的自然选择过程的独特见解。为了评估的模式和目标的选择，我们研究了最近发现的狒狒杂交区在赞比亚的卡富埃河流域，在那里的Kinda狒狒（Papio kindae）和灰脚的chacma狒狒（P. ursinus griseipes）与杂交共存。我们使用双消化RADseq在14，962个可变的全基因组常染色体标记处对狒狒进行基因分型。我们比较了来自这个全基因组数据集的祖先模式与以前报道的来自DNA和Y染色体来源的祖先。我们还拟合了贝叶斯基因组无性系模型来扫描具有极端渐渗模式的基因。我们发现，有点狒狒Y染色体已渗透到更大程度上比线粒体DNA或常染色体的物种边界。我们还发现了JAK/STAT信号通路中总体限制性基因渗入的证据。与包括人类在内的其他物种的结果相呼应，我们发现了免疫相关基因或途径（包括toll样受体途径、凝血途径和LY 96基因）增强和/或定向渗入的证据。最后，我们显示增强的渐渗和多余的查克玛狒狒血统的精子尾部基因ODF 2。总之，我们的研究结果阐明了在灵长类动物系统中渐渗杂交的动力学，同时确定可能在选择下的基因和途径。
Hybridization in nature offers unique insights into the process of natural selection in incipient species and their hybrids. In order to evaluate the patterns and targets of selection, we examine a recently discovered baboon hybrid zone in the Kafue River Valley of Zambia, where Kinda baboons (Papio kindae) and gray-footed chacma baboons (P. ursinus griseipes) coexist with hybridization. We genotyped baboons at 14,962 variable genome-wide autosomal markers using double-digest RADseq. We compare ancestry patterns from this genome-wide dataset to previously reported ancestry from mitochondrial-DNA and Y-chromosome sources. We also fit a Bayesian genomic cline model to scan for genes with extreme patterns of introgression. We show that the Kinda baboon Y chromosome has penetrated the species boundary to a greater extent than either mitochondrial DNA or the autosomal chromosomes. We also find evidence for overall restricted introgression in the JAK/STAT signaling pathway. Echoing results in other species including humans, we find evidence for enhanced and/or directional introgression of immune-related genes or pathways including the toll-like receptor pathway, the blood coagulation pathway, and the LY96 gene. Finally we show enhanced introgression and excess chacma baboon ancestry in the sperm tail gene ODF2. Together, our results elucidate the dynamics of introgressive hybridization in a primate system while identifying genes and pathways possibly under selection.
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影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
4.9
作者：
Charpentier, M. J. E.;Fontaine, M. C.;Tung, J.
通讯作者：
Tung, J.
DOI：
10.1007/bf00374056
发表时间：
1934-01-01
期刊：
ZEITSCHR ZELLJORSCH U MIKROSK ANAT
影响因子：
--
作者：
DOBZHANSKY, TH.
通讯作者：
DOBZHANSKY, TH.
影响因子：
9.8
作者：
Dannemann M;Andrés AM;Kelso J
通讯作者：
Kelso J
影响因子：
14.9
作者：
Benson, G
通讯作者：
Benson, G